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Nanogels for Pharmaceutical and Biomedical Applications and Their Fabrication Using 3D Printing Technologies

机译：用于制药和生物医学应用的纳米凝胶及其使用3D打印技术的制备

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摘要

Nanogels are hydrogels formed by connecting nanoscopic micelles dispersed in an aqueous medium, which give an opportunity for incorporating hydrophilic payloads to the exterior of the micellar networks and hydrophobic payloads in the core of the micelles. Biomedical and pharmaceutical applications of nanogels have been explored for tissue regeneration, wound healing, surgical device, implantation, and peroral, rectal, vaginal, ocular, and transdermal drug delivery. Although it is still in the early stages of development, due to the increasing demands of precise nanogel production to be utilized for personalized medicine, biomedical applications, and specialized drug delivery, 3D printing has been explored in the past few years and is believed to be one of the most precise, efficient, inexpensive, customizable, and convenient manufacturing techniques for nanogel production.
机译：纳米凝胶是通过将分散在水性介质中的纳米级胶束连接而形成的水凝胶，这提供了将亲水性有效负载并入胶束网络外部和疏水性有效负载并入胶束核心的机会。已经研究了纳米凝胶的生物医学和药学应用，用于组织再生，伤口愈合，外科手术装置，植入以及经口，直肠，阴道，眼和经皮给药。尽管它仍处于开发的早期阶段，但是由于越来越多的精确纳米凝胶生产需求用于个性化医学，生物医学应用和专门的药物递送，因此在过去的几年中，人们一直在探索3D打印技术，并且据信一种用于纳米凝胶生产的最精确，高效，廉价，可定制和方便的制造技术之一。

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