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首页> 外文期刊>MBio >Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin
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Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin

机译：当代的甲型H1，H6，H7，H10和H15禽流感病毒血凝素基因编码类似于1918年大流行病毒H1血凝素的哺乳动物毒力因子

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Zoonotic avian influenza virus infections may lead to epidemics or pandemics. The 1918 pandemic influenza virus has an avian influenza virus-like genome, and its H1 hemagglutinin was identified as a key mammalian virulence factor. A chimeric 1918 virus expressing a contemporary avian H1 hemagglutinin, however, displayed murine pathogenicity indistinguishable from that of the 1918 virus. Here, isogenic chimeric avian influenza viruses were constructed on an avian influenza virus backbone, differing only by hemagglutinin subtype expressed. Viruses expressing the avian H1, H6, H7, H10, and H15 subtypes were pathogenic in mice and cytopathic in normal human bronchial epithelial cells, in contrast to H2-, H3-, H5-, H9-, H11-, H13-, H14-, and H16-expressing viruses. Mouse pathogenicity was associated with pulmonary macrophage and neutrophil recruitment. These data suggest that avian influenza virus hemagglutinins H1, H6, H7, H10, and H15 contain inherent mammalian virulence factors and likely share a key virulence property of the 1918 virus. Consequently, zoonotic infections with avian influenza viruses bearing one of these hemagglutinins may cause enhanced disease in mammals. >IMPORTANCE Influenza viruses from birds can cause outbreaks in humans and may contribute to the development of pandemics. The 1918 pandemic influenza virus has an avian influenza virus-like genome, and its main surface protein, an H1 subtype hemagglutinin, was identified as a key mammalian virulence factor. In a previous study, a 1918 virus expressing an avian H1 gene was as virulent in mice as the reconstructed 1918 virus. Here, a set of avian influenza viruses was constructed, differing only by hemagglutinin subtype. Viruses with the avian H1, H6, H7, H10, and H15 subtypes caused severe disease in mice and damaged human lung cells. Consequently, infections with avian influenza viruses bearing one of these hemagglutinins may cause enhanced disease in mammals, and therefore surveillance for human infections with these subtypes may be important in controlling future outbreaks.
机译：人畜共患的禽流感病毒感染可能导致流行病或大流行。 1918年的大流行性流感病毒具有禽流感病毒样的基因组，其H1血凝素被确定为关键的哺乳动物毒力因子。表达当代禽H1血凝素的嵌合1918病毒显示出与1918病毒无法区分的鼠类致病性。在这里，在禽流感病毒主链上构建了同基因嵌合禽流感病毒，仅在表达的血凝素亚型方面有所不同。与H2-，H3-，H5-，H9-，H11-，H13-，H14相反，表达禽类H1，H6，H7，H10和H15亚型的病毒在小鼠中具有致病性，在正常人支气管上皮细胞中具有细胞致病性-和表达H16的病毒。小鼠的致病性与肺巨噬细胞和中性粒细胞募集有关。这些数据表明，禽流感病毒血凝素H1，H6，H7，H10和H15含有内在的哺乳动物毒力因子，可能具有1918年病毒的关键毒力特性。因此，带有这些血凝素之一的禽流感病毒的人畜共患感染可引起哺乳动物疾病的增强。 >重要：禽流感病毒可引起人类暴发，并可能导致大流行病的发展。 1918年的大流行性流感病毒具有类似禽流感病毒的基因组，其主要表面蛋白H1亚型血凝素被确定为关键的哺乳动物毒力因子。在先前的研究中，表达禽类H1基因的1918病毒在小鼠中的毒性与重建的1918病毒相同。在这里，构建了一套禽流感病毒，只是血凝素亚型不同。具有禽类H1，H6，H7，H10和H15亚型的病毒在小鼠中引起严重疾病，并破坏了人类肺细胞。因此，带有这些血凝素之一的禽流感病毒感染可能导致哺乳动物疾病加剧，因此，监测这些亚型的人类感染对于控制未来的爆发可能很重要。

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