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首页> 外文期刊>Frontiers in Human Neuroscience >Time-based prospective memory functioning in mild cognitive impairment associated with Parkinson’s disease: relationship with autonomous management of daily living commitments
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Time-based prospective memory functioning in mild cognitive impairment associated with Parkinson’s disease: relationship with autonomous management of daily living commitments

机译：基于时间的前瞻性记忆在与帕金森氏病相关的轻度认知障碍中的作用：与日常生活承诺的自主管理的关系

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Objective : Prospective memory (PM), that is, the ability to keep in memory and carry out intentions in the future, is reported to be impaired in individuals with Parkinson’s disease (PD). PM failure may be also associated with reduced daily living functioning in these patients. Little is known, however, about the relationship between mild cognitive impairment (MCI) and time-based PM functioning in PD patients and the possible impact of PM deficits on patients’ autonomy in daily living. Here we aimed to investigate whether MCI associated with PD affects time-based PM. We also wished to determine whether PM impairment accounts for reduced autonomous management of medication in these patients. Method : The study included 48 PD patients with MCI, 33 PD patients without cognitive disorders (PDN) and 20 healthy controls. The time-based PM procedure required that subjects perform an action after a fixed time. The PM procedure was incorporated in the standard neuropsychological assessment. One score was computed for the ability to retrieve the intention (prospective component) and one for remembering the action to be executed (retrospective component). The Pill Questionnaire was administered to assess the ability to manage medication. Results : PD patients with MCI performed less accurately in the PM procedure than HC and tended to perform poorer than PDN. Moreover, in PD patients with MCI, accuracy on the prospective component of the PM task and performance on the Modified Card Sorting Test significantly predicted the ability to manage medication. Conclusions : Results document that reduced efficiency of time-based PM processes in PD is specifically related to the presence of MCI. The same data indicate that PM weakness may be associated with impaired daily living functioning and decreased autonomy.
机译：目的：据报道，患有帕金森氏病（PD）的人的前瞻性记忆（PM），即记忆和将来执行意图的能力受到损害。这些患者的PM衰竭也可能与日常生活功能降低有关。然而，关于帕金森病患者的轻度认知障碍（MCI）和基于时间的PM功能之间的关系以及PM缺陷对患者日常生活中自主性的可能影响知之甚少。在这里，我们旨在调查与PD相关的MCI是否会影响基于时间的PM。我们还希望确定PM损伤是否导致这些患者的药物自主管理减少。方法：该研究包括48例MCI的PD患者，33例无认知障碍（PDN）的PD患者和20例健康对照。基于时间的PM程序要求受试者在固定时间后执行操作。 PM程序已纳入标准的神经心理学评估中。计算出一项得分的能力来检索意图（预期组成部分），获得一个得分以记住要执行的动作（追溯组成部分）。服用了药丸问卷以评估药物治疗的能力。结果：MCI的PD患者在PM程序中的表现不如HC，并且往往比PDN差。此外，在患有MCI的PD患者中，PM任务的预期组成部分的准确性和改良卡片分类测试的性能显着预测了药物管理的能力。结论：结果文件表明，PD中基于时间的PM流程效率降低与MCI的存在特别相关。相同的数据表明，PM虚弱可能与日常生活功能受损和自主能力下降有关。

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