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The study of differentially expressed serum protein in patients with different traditional chinese medicine syndromes of knee osteoarthritis

机译：膝骨关节炎不同中医证型患者血清蛋白差异表达的研究

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Objectives: To study the distribution characteristics of patients with knee osteoarthritis (KOA) of different traditional Chinese medicine (TCM) syndromes and to reveal the differences from the perspectives of expressions of serum inflammatory indicators. Methods: One hundred and thirty-four patients with KOA treated in our hospital from January 2013 to March 2016 and referring to TCM syndrome types were included in the study and were divided into three types: Yin deficiency in kidney and liverendon and vesselstasissyndrome,s pleen and kidney deficiency wet injection the osteomere syndrome, kidney Yang deficiency and weakphlegm stasis syndrome; 24 healthy persons who took physical examination in our hospital were selected as the normal control group. Patients' blood was collected in the morning as the blood samples, and the levels of inflammatory factors (5-TH, interleukin-6 [IL-6], and tumor necrosis factor-α [TNF-α]) were measured in serum. Results: The most common TCM syndrome of KOAin the clinical trialsis Yin deficiency in kidney and liverendon and vesselstasissyndrome, the percents of spleen and kidney deficiencywet injection the osteomere syndrome and kidney Yang deficiency and weakphlegm stasissyndrome are near, the former is slightly higher than the latter by 3.97%. The levels of IL-6 and TNF-α in the three groups were significantly higher than those in the normal control group, whereas the 5-TH level was significantly lower in the three groups than that in the normal control group ( P 0.05). The levels of IL-6 and TNF-α in the kidney Yang deficiency and weakphlegm stasis syndrome group were significantly higher than the next two TCM syndrome groups ( P 0.05), whereas the 5-TH level in the kidney Yang deficiency and weakphlegm stasis syndrome group was significantly lower than the next two TCM syndrome groups ( P 0.05). Conclusions: Yin deficiency in kidney and liverendon and vessel stasis syndrome is the most common TCM syndrome of KOA in the clinical trials. The levels of inflammatory factors (5 TH, IL 6, and TNF α) in serum had a close relationship with KOA. In terms of the perspectives of expressions of serum inflammatory indicators, the most serious TCM syndrome of KOA is kidney Yang deficiency and weakphlegm stasis syndrome.
机译：目的：研究不同中医证型的膝骨关节炎患者的分布特点，从血清炎症指标表达的角度揭示其差异。方法：将2013年1月至2016年3月在我院就诊的134例KOA患者按中医证型进行研究，分为肾，肝，肌腱阴虚，血管痉挛综合征三种类型。脾肾亏虚湿法注射骨质疏松综合症，肾阳虚虚弱痰瘀综合症。选择我院体检的24名健康人作为正常对照组。早晨采集患者血液作为血样，并测量血清中的炎症因子（5-TH，白介素-6 [IL-6]和肿瘤坏死因子-α[TNF-α]）的水平。结果：在临床试验中，KOA最常见的中医证候是肾，肝，肌腱和血管峡综合征的阴虚，脾肾亏虚的百分比，湿注射的骨小骨证与肾阳虚，弱痰痰证相近。略高于后者3.97％。三组的IL-6和TNF-α水平显着高于正常对照组，而三组的5-TH水平显着低于正常对照组（P <0.05） 。肾阳虚和弱痰痰证组的IL-6和TNF-α水平显着高于接下来的两个中医证候组（P <0.05），而肾阳虚和气虚痰瘀证组的5-TH水平明显高于中医证候组。弱痰瘀证组明显低于接下来的两个中医证候组（P <0.05）。结论：肾，肝，腱，血管淤滞综合征阴虚是临床研究中最常见的KOA中医证候。血清中炎性因子（5 TH，IL 6和TNFα）的水平与KOA密切相关。从血清炎症指标表达的角度来看，KOA最严重的中医证候是肾阳虚和痰瘀阻证。

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