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Legacy of mental Illness: A family with unusual genetic penetration

机译：精神疾病的传承：一个遗传渗透异常的家庭

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Mental illnesses are multifactorial disorders caused by the interaction of genetic and environmental factors. Multiple lines of evidence suggest that the roles of genetic and environmental factors depend on each other. ?The aim of the report is to share the presentation of different psychiatric illnesses in generations of a family. A 31 year old male, unmarried, studied up to class eight, unemployed, muslim, non smoker, with average intelligence, hailing from the Dhaka with lower-middle economic background was diagnosed as a case of Schizophrenia. He has very strong family history of mental illness more prominent in male and persistent in generations. Males were affected by schizophrenia, personality disorder and substance related disorder, whereas only one female was affected by depression with suicide. In the patient’s generation, two males were affected with schizophrenia, two male with personality disorder and two with substance related disorder without any presentation in female. In previous generation one male was affected with personality disorder (Father) and one female was suicide committer due to depression (Aunt). There was also presence of male psychotic patients in the grandmother’s family of the patient. Family, twin and adoption studies have shown that, for schizophrenia, autism, manic depressive illness, major depression, attention deficit hyperactivity disorder, panic disorder and other mental illnesses, the transmission of risk was heredity. Our case strongly made us curious to search for any common genetic link between different mental illnesses running in the family.
机译：精神疾病是由遗传和环境因素的相互作用引起的多因素疾病。多条证据表明，遗传因素和环境因素的作用相互依赖。该报告的目的是在一个家庭世代中分享各种精神疾病的表现。一名31岁的男性未婚，研究到八级，失业，穆斯林，不吸烟，平均智力，来自达卡，来自中低等经济背景，被诊断为精神分裂症。他有很强的精神病家族史，在男性中尤为突出，并在几代人中持续存在。男性患有精神分裂症，人格障碍和与物质有关的疾病，而只有一名女性患有自杀性抑郁症。在这一代患者中，两名男性患有精神分裂症，两名男性患有人格障碍，两名男性患有物质相关性障碍，而女性则没有任何表现。在上一代中，一名男性患有人格障碍（父亲），一名女性因抑郁而自杀（姨妈）。病人的祖母家中也有男性精神病患者。家庭，双胞胎和收养研究表明，对于精神分裂症，自闭症，躁狂抑郁症，重度抑郁症，注意力缺陷多动障碍，恐慌症和其他精神疾病，风险的传递是遗传。我们的案例强烈地促使我们好奇地寻找家庭中各种精神疾病之间的任何常见遗传联系。

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