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首页> 外文期刊>Medical and Health Science Journal >Correlating alleles of genes LPH, CALCR, COL1A1, VDR with the indicators of bone tissue mineral density in female population of Eastern Kazakhstan
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Correlating alleles of genes LPH, CALCR, COL1A1, VDR with the indicators of bone tissue mineral density in female population of Eastern Kazakhstan

机译：哈萨克斯坦东部女性人群中LPH，CALCR，COL1A1，VDR基因的等位基因与骨组织矿物质密度的指标相关

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The paper attemts to identify distribution of frequency of alleles of LPH, CALCR, COL1A1, VDR genes and correlation with indicators of bone tissue mineral density (BTMD) in population of reproductive age females in the Eastern region of Kazakhstan. Genetic research has been conducted on 475 females exhibiting LPH, CALCR, COL1A1, VDR genes, presence of which, according to previous research, is due to confirmed increased risk of osteoporosis. Examined females were distributed by race: 213 women were of European descent, 262 -Asian (Turkic). Women of Turkic descent presented a much elevated rate of alleles pertaining to the genes associated with the risk of reduced BTMD. Moreover, correlation has been established between osteopeniac syndrome and existence of certain recessive alleles in heterozygous cases.
机译：本文试图确定哈萨克斯坦东部地区育龄女性群体中LPH，CALCR，COL1A1，VDR基因的等位基因频率分布及其与骨组织矿物质密度（BTMD）指标的相关性。已经对475名表现出LPH，CALCR，COL1A1，VDR基因的女性进行了遗传研究，根据先前的研究，这些女性的存在是由于确认的骨质疏松风险增加。受检查的女性按种族分布：213名欧洲血统的女性，262名亚洲血统（突厥人）。突厥后裔妇女表现出与降低BTMD风险相关的基因有关的等位基因比率高得多。此外，在杂合症病例中，骨质减少综合征与​​某些隐性等位基因的存在之间已经建立了相关性。

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