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Nanocapsular forms of preparations in preclinical studies

机译：临床前研究中制剂的纳米囊形式

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The paper examines preclinical study of nanocapsule delivery system, particularly the influence of nanocapsule with a vasodilator in the process of programmed myocardial cells death. Isosorbide dinitrate was loaded in nanocapsules. To investigate the effect nanocapsule isosorbide dinitrate on the process of apoptosis in cardiomyocytes, a series of experimental works were performed. For this purpose, a model of coronary insufficiency in 4 groups of animals were elaborated. The experimental works on laboratory animals were conducted in accordance with requirements of the European Convention for the protection of vertebrate animals. The first preclinical trials showed the presence of specific activity of obtained drugs. The basis of nanocapsular system was phosphatidylinositol, and the active loading substances were alprostadil, interferon alpha.
机译：本文审查了纳米胶囊递送系统的临床前研究，特别是纳米血管与血管扩张剂在程序性心肌细胞死亡过程中的影响。将硝酸异山梨酯装载在纳米胶囊中。为了研究纳米硝酸异山梨酯胶囊对心肌细胞凋亡过程的影响，进行了一系列实验工作。为了这个目的，建立了4组动物的冠状动脉供血不足的模型。实验动物的实验工作是根据《欧洲保护脊椎动物公约》的要求进行的。最初的临床前试验表明，所获得药物具有特定活性。纳米囊系统的基础是磷脂酰肌醇，活性负载物质是前列地尔，干扰素α。

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