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首页> 外文期刊>Medical and Health Science Journal >Characteristics of the effect of insecticide karate on the metabolism of the nucleic acids and proteins in the subcellular fractions of the liver and intestine
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Characteristics of the effect of insecticide karate on the metabolism of the nucleic acids and proteins in the subcellular fractions of the liver and intestine

机译：空手道杀虫剂对肝脏和肠道亚细胞部分核酸和蛋白质代谢影响的特征

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Experiments were performed on the outbred white rats of mass 120-250 g in 2 stages. Analysis of the results obtained showed that in acute poisoning with pesticide Karate the acute decrease in RNA and DNA occurred in the subcellular elements of liver and intestine mucosa during the first 7 days of experiment with subsequent normalization of the levels during the following 7 and 15 days. In chronic poisoning the number of RNA in the studied hepatic biomedium decreased in the homogenate to 66.47 and 55%, in the nucleic fractions to 64-62.5%, and in the supernatant fluid - to 52.6-48%; and in the small intestine - from 55.6% to 64.6%, respectively, according to the time of experiment. The DNA level reduced from 20% to 55%. In acute and chronic poisoning with pesticides of group pyrethroids, concentration of nucleic acids sharply reduced in the elements of liver and intestinal mucosa, that indicated about possibility of the inhibition of the DNA and RNA synthesis, which effect on the synthesis of protein in the cells.
机译：在两个阶段对质量为120-250 g的近交白鼠进行了实验。对所得结果的分析表明，在用空手道杀虫剂进行急性中毒时，实验的前7天中，肝脏和肠粘膜的亚细胞成分中的RNA和DNA急剧下降，随后在随后的7天和15天中将其水平恢复正常。在慢性中毒中，被研究的肝脏生物介质中的RNA数量在匀浆中降至66.47和55％，在核酸级分中降至64-62.5％，在上清液中降至52.6-48％;根据实验时间，在小肠中分别为55.6％至64.6％。 DNA水平从20％降低至55％。在使用拟除虫菊酯类农药进行的急性和慢性中毒中，肝脏和肠粘膜成分中核酸的浓度急剧降低，这表明可能抑制DNA和RNA的合成，从而影响细胞中蛋白质的合成。

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