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Percentage of competent cells in skin inflammatory infiltration

机译：皮肤炎症浸润中感受态细胞的百分比

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Immunological reactions, which develop in response to inflammatory stimuli, are caused by the presence of imunologically competent cells situated in the skin. The aim of this study was the comparison of the relative number of cells expressing CD3, CD4, CD. 8, CS20, CD68, CD25 (IL-2R), CD123 (IL-3R), CDw130 (IL-6R), CD120a (TNF-a) and TNF-aR (55kDa) surface antigens, cytokine receptors or cytokines present in skin (around blood vessels and skin appendages) and to determine percentage of cells in inflammatory infiltrates around ingrowing nailfolds in children. In inflammatory infiltrates around ingrowing nailfolds a significant decrease of the percentage of CD3 cells (T lymphocytes) has been observed, while the percentage of CD68 cells (macrophages) and CD20 cells (B lymphocytes) has been found to be increased. Similarly, the relative number of all expressing IL3, IL-6, TNF-a cytokine receptor and cell producing TNF-a molecules was increased. The results of our studies suggest that such phenotypic characteristics of immunocompetent cell infiltrate in skin around ingrowing nailfold in children is a reflection of an immunological reaction and defence mechanism of skin to bacterial antigen.
机译：响应于炎症刺激而产生的免疫反应是由皮肤中存在免疫功能的细胞引起的。这项研究的目的是比较表达CD3，CD4，CD的细胞的相对数量。 8，CS20，CD68，CD25（IL-2R），CD123（IL-3R），CDw130（IL-6R），CD120a（TNF-a）和TNF-aR（55kDa）表面抗原，细胞因子受体或细胞因子（在血管和皮肤附件周围），并确定儿童向内生长的指甲皱褶周围炎性浸润中的细胞百分比。在向内生长的甲皱周围的炎性浸润中，观察到CD3细胞（T淋巴细胞）的百分比显着下降，而CD68细胞（巨噬细胞）和CD20细胞（B淋巴细胞）的百分比却增加了。同样，所有表达IL3，IL-6，TNF-α细胞因子受体和产生细胞的TNF-α分子的相对数量均增加。我们的研究结果表明，儿童的内生甲皱周围浸润的皮肤中具有免疫能力的细胞浸润的这种表型特征反映了皮肤对细菌抗原的免疫反应和防御机制。

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