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Proliferative activity of metastatic liver tumors based on the evaluation of MAPK sub-unit p42s activity

机译：基于MAPK亚基p42s活性评估的转移性肝肿瘤增殖活性

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The aim of this study was to evaluate the activity of the p42 MAPK subunit (mitogen activated protein kinase), one of the most important factors of proliferation and differentiation, in metastatic liver tumors. The material comprised liver biopsies collected from 16 patients during large bowel cancer surgery. We evaluated the activity of MAPK from the central part of each tumor, the border region (between tumor and macroscopically uninvolved liver) and samples located far away from the metastases. This was determined by means of the westernblot technique with IgG antibodies directed against MAPK. 13 cases presented with an increased MAPK level in samples collected from liver tumors. In 9 of 13 cases the highest MAP kinase activity was noted in the peripheral part of the tumor. Our results correlate with the supposed role of the kinase cascade in the formation and growth of metastatic liver tumors. The elevated MAPK level in the peripheral part of the tumor can explain the rapid tumor growth and the high percentage of tumor recurrence following surgery. Thus, in cases of liver metastases the tumor tissue should be resected with a wide margin.
机译：这项研究的目的是评估转移性肝肿瘤中最重要的增殖和分化因子之一p42 MAPK亚基（有丝分裂原活化的蛋白激酶）的活性。该材料包括在大肠癌手术期间从16名患者收集的肝活检标本。我们评估了每个肿瘤的中心部分，边界区域（肿瘤与宏观上不相关的肝脏之间）和远离转移灶的样本中MAPK的活性。这是通过westernblot技术结合针对MAPK的IgG抗体确定的。 13例肝癌样本中MAPK水平升高。在13例中的9例中，在肿瘤的外围部分发现了最高的MAP激酶活性。我们的研究结果与激酶级联在转移性肝肿瘤的形成和生长中的假定作用有关。肿瘤外围部分MAPK水平升高可以解释肿瘤的快速生长和手术后肿瘤复发的高百分比。因此，在肝转移的情况下，肿瘤组织应大范围切除。

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