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首页> 外文期刊>Medical Devices: Evidence and Research >Porous titanium-coated polyetheretherketone implants exhibit an improved bone–implant interface: an in vitro and in vivo biochemical, biomechanical, and histological study
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Porous titanium-coated polyetheretherketone implants exhibit an improved bone–implant interface: an in vitro and in vivo biochemical, biomechanical, and histological study

机译：多孔钛涂层的聚醚醚酮植入物具有改善的骨-植入物界面：体外和体内生化，生物力学和组织学研究

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Purpose: Spinal interbody fusion cages are designed to provide immediate stabilization for adjoining vertebrae and ideally enable bony ingrowth to achieve successful integration. For such an implant, cells must be able to attach, move, grow, and differentiate on its surface. These cellular interactions are dependent on how the implant surface enables the coating and binding of blood and tissue fluid proteins that support cell adhesion. The purpose of this study was to evaluate the in vitro and in vivo osteoblast cell–implant surface interactions that result in osseointegration onto a surface composed of plasma-sprayed titanium on a polyetheretherketone (PEEK) substrate or titanium-coated PEEK (Ti-PEEK) (PlasmaporeXP?) as compared to uncoated PEEK implants. Materials and methods: The influence of the Ti-PEEK surface modification on the biochemical, biomechanical, and histological properties at the bone–implant interface is demonstrated both in vitro using simulated bone-forming cell culture experiments and in vivo using a 12- and 24-week ovine implant model. Results: Osteoblast-like cells attached to the Ti-PEEK surface upregulated early bone-forming activity as measured by an increase in transcription and translation of ALP and BMP-2 when compared to cells on PEEK. Similarly, a significant increase in new bone formation, bony apposition, and pullout strength was demonstrated on Ti-PEEK implants when compared to PEEK implants at 12 and 24 weeks in an ovine implant in vivo model. Conclusion: The study shows that the Ti-PEEK surface demonstrated enhanced osseointegrative properties compared to PEEK both in vitro and in vivo.
机译：目的：脊椎椎间融合器的设计旨在为相邻椎骨提供即时稳定，并理想地使骨向内生长以实现成功的融合。对于这种植入物，细胞必须能够在其表面附着，移动，生长和分化。这些细胞相互作用取决于植入物表面如何使支持细胞粘附的血液和组织液蛋白形成涂层和结合。这项研究的目的是评估体外和体内成骨细胞与植入物之间的表面相互作用，该相互作用导致骨整合到聚醚醚酮（PEEK）或钛涂层PEEK（Ti-PEEK）上等离子喷涂钛组成的表面上（PlasmaporeXP？）与未涂覆的PEEK植入物相比。材料和方法：Ti-PEEK表面修饰对骨-植入物界面生化，生物力学和组织学特性的影响已在体外通过模拟骨形成细胞培养实验得到了证明，在体内使用12和24周绵羊植入物模型。结果：与PEEK上的细胞相比，附着在Ti-PEEK表面上的成骨样细胞上调了早期成骨活性，这是通过ALP和BMP-2转录和翻译的增加来衡量的。同样，在绵羊植入物体内模型中，与PEEK植入物相比，在12周和24周时，Ti-PEEK植入物证明了新骨形成，骨并置和拔出强度的显着增加。结论：研究表明，与PEEK相比，Ti-PEEK表面在体外和体内均表现出增强的骨整合性能。

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