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首页> 外文期刊>Medical science monitor : >Non-Hodgkin's lymphomas with primary localization in large bowel and rectum
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Non-Hodgkin's lymphomas with primary localization in large bowel and rectum

机译：非霍奇金淋巴瘤主要位于大肠和直肠

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From 1989, at the Department of Medical Oncology of the Institute for Oncology and Radiology in Belgrade, seven patients with primary NHL of large bowel and rectum have been observed and treated, 3 males and 4 females. In 3 patients an urgent laparotomy without previous diagnostic procedures was performed, while 4 patients had laparotomy only after radiographic and endoscopic diagnosis of a tumor. Six patients had radical surgery and 1 palliative only. Five patients had lymphoma localized in cecoascedental part of colon (2 centroblastic, 1 lymphoplasmocytic, 1 Burkitt and 1 Burkitt's like), 1 patient had it in the transversal part of colon (centroblastic), and one in the rectum (diffuse centrocytic). By further investigation, in 2 cases with localization within transversal part of colon and rectum no other sites of NHL were found. They are under regular controls with 45+ and 45+ months disease free survival. Out of 5 patients with localization within cecum or ascendent part of colon, in 2 cases with Burkitt/Burkitt-like histology retroperitoneal lymphadenopathy were found, one female had NHL central propagation, and the other one lymphoma generalization. Both patients had early death from lymphoma. The remaining three patients following chemotherapy with the ProMACE regimen (as they too had a post laparotomy stage II disease) achieved a complete response lasting for 36+, 41+ and 66+ months. Since the median survival in our group of patients is at the moment 41+ months, and the median has not yet been reached, our experience does not confirm literature data claiming bad prognosis of primary NHL of the colon and rectum. A long disease free survival can be obtained in these patients either with surgery only or surgery+chemotherapy, depending on disease stage and possibly initial topographic localization.
机译：从1989年开始，在贝尔格莱德肿瘤和放射学研究所的医学肿瘤学系，观察并治疗了7名大肠和直肠原发性NHL患者，其中3例男性和4例女性。在3例患者中进行了没有事先诊断程序的紧急剖腹手术，而4例患者仅在影像学和内镜诊断出肿瘤后才进行剖腹手术。 6例接受了根治性手术，仅1例姑息。 5例淋巴瘤位于结肠的盲骨先端部分（2个中心胶质，1个淋巴浆细胞性，1个Burkitt和1个Burkitt样），1个患者在结肠的横切部分（中心胶质），以及一个在直肠（弥漫性中心质）。通过进一步调查，在2例位于结肠和直肠横断部分内的病例中，未发现其他NHL部位。他们处于常规控制之下，无病生存期超过45和45个月以上。在5例位于盲肠或结肠上升部位的患者中，发现2例具有Burkitt / Burkitt样组织学的腹膜后淋巴结肿大，其中一名女性患有NHL中心扩散，另一名患有淋巴瘤泛化。两名患者均因淋巴瘤而早逝。其余三名接受ProMACE方案化疗的患者（因为他们也有开腹手术后的II期疾病）获得了完整的缓解，持续了36 +，41 +和66+个月。由于本组患者的中位生存期目前已超过41个月，并且尚未达到中位值，因此我们的经验并未证实声称结肠癌和直肠原发性NHL预后不良的文献资料。这些患者仅需手术或手术+化学疗法即可获得长期无病生存，具体取决于疾病阶段和可能的初始地形定位。

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