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Evaluating the profile of selected cytokines in patients with food allergy and chronic gastritis

机译：评估食物过敏和慢性胃炎患者中所选细胞因子的概况

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Introduction: Evaluating the profile of selected cytokines in patients with food allergy and chronic gastritis. Cytokines are produced by many cells and they play a role of mediators in the development of local and systemic inflammatory reaction. The aim of the study was to determine serum concentrations of IL-4, IL-5, IL-8, TNFa in patients with chronic gastritis and food allergy, who had been infected with H. pylori.Material and methods: The study was conducted on patients with atopic diathesis, who were allergic to certain foods. The study group consisted of 71 patients, including 42 females aged 16-54 years (mean age 35.5 years) and 29 males aged 18-60 years (mean age 36.2 years). One control group was formed of 40 non-atopic patients aged 18-56 years (mean age 34.8 years), suffering from chronic gastritis. The other control group consisted of 30 subjects with the diagnosis of functional dyspepsia. Serum levels of selected cytokines were determined with the kits manufactured by ENDOGEN (Cambridge MA, USA) using enzyme immunoassay ELISA. The concentrations of parameters were determined in two tests and they were given as mean value.Results: Mean serum Il-4 level in atopic patients was 27.85 pg/ml, while it was 13.26 pg/ml in non-atopic subjects with chronic gastritis and 4.3 pg/ml in patients with functional dyspepsia. The concentration of IL-5 ranged between 0 and 111.3 pg/ml (mean value: 7.43 pg/ml) in subjects with food allergy. Comparative analysis of IL-4 and IL-5 concentrations in atopic patients and in control subjects showed the presence of statistically significant differences (p0.001). The remaining cytokines, i.e. IL-8 and TNFα showed a significant increase in serum levels in patients chronic gastritis when compared to the subjects with functional dyspepsia, without inflammatory changes.Conclusions: Chronic exposure of the patients with food allergy to a given food allergen makes the levels of IL-4 and IL-5 rise. In atopic subjects with chronic gastritis and H. pylori infection, the increase in IL-4, IL-5, IL-8 and TNFα levels suggests that both infectious and allergic factors play an important role in the pathogenesis of inflammation.
机译：简介：评价患有食物过敏和慢性胃炎的患者所选细胞因子的概况。细胞因子是由许多细胞产生的，它们在局部和全身性炎症反应的发展中起着介质的作用。本研究的目的是确定感染了幽门螺杆菌的慢性胃炎和食物过敏患者的血清IL-4，IL-5，IL-8，TNFa的浓度。材料和方法：对某些食物过敏的特应性素质患者。该研究组由71位患者组成，其中42位女性年龄在16-54岁（平均年龄35.5岁）和29位男性年龄在18-60岁（平均年龄36.2岁）。一个对照组由40名年龄在18-56岁（平均年龄34.8岁）的非过敏性患者组成，他们患有慢性胃炎。另一对照组由30名诊断为功能性消化不良的受试者组成。使用酶免疫测定ELISA，由ENDOGEN（美国马萨诸塞州剑桥市）制造的试剂盒测定所选细胞因子的血清水平。结果：在特应性患者的平均血清IL-4水平为27.85 pg / ml，在非特应性慢性胃炎和非胃炎患者中为13.26 pg / ml。功能性消化不良的患者为4.3 pg / ml。在患有食物过敏的受试者中，IL-5的浓度在0至111.3 pg / ml之间（平均值：7.43 pg / ml）。对特应性患者和对照对象中IL-4和IL-5浓度的比较分析表明存在统计学上的显着差异（p <0.001）。与患有功能性消化不良的患者相比，慢性胃炎患者中剩余的细胞因子（即IL-8和TNFα）的血清水平显着升高，而无炎症变化。结论：患有食物过敏的患者对给定的食物过敏原的长期暴露使IL-4和IL-5的水平升高。在患有慢性胃炎和幽门螺杆菌感染的特应性受试者中，IL-4，IL-5，IL-8和TNFα水平的升高表明感染性和过敏性因素在炎症的发病机理中均起着重要作用。

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