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DNA microarray technology and application

机译:DNA微阵列技术与应用

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DNA microarrays (collections of DNA probes arranged on a shared base) have recently enlarged the spectrum of commercially available laboratory-ready kits in molecular biology. They are powerful new tools for the investigation of global changes in gene expression profiles in cells and tissues. Their assembly process is automatized and the DNA microarrays are further miniaturized. The DNA microarrays are used in search for various specific genes (e.g. connected with an infectious agent) or in gene polymorphism and expression analysis. They will be widely used to investigate expression of various genes connected with various diseases in order to find causes of these diseases and to enable their accurate treatment. Since the DNA microarray assembly technology has been based on methods widely used in the semiconductor industry, we can expect a rapid onset of the routine use of this revolutionary device.
机译:DNA微阵列(排列在共享碱基上的DNA探针的集合)最近扩大了分子生物学中可商购的实验室就绪试剂盒的范围。它们是研究细胞和组织中基因表达谱的整体变化的强大新工具。它们的组装过程自动化,DNA微阵列进一步小型化。 DNA微阵列用于搜索各种特定基因(例如与感染因子连接)或用于基因多态性和表达分析。它们将被广泛用于研究与各种疾病相关的各种基因的表达,以找到这些疾病的病因并能够对其进行准确的治疗。由于DNA微阵列组装技术是基于半导体工业中广泛使用的方法,因此我们可以预期这种革命性设备的常规使用会迅速开始。

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