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首页> 外文期刊>Mediators of inflammation >Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases: Potential Role in Macrophage-Mediated Inflammatory Diseases
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Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases: Potential Role in Macrophage-Mediated Inflammatory Diseases

机译：吲哚胺2，3-双加氧酶和色氨酸代谢产物在传染病中的显著作用：在巨噬细胞介导的炎性疾病中的潜在作用

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Indoleamine 2,3-dioxygenase 1 (IDO1), the L-tryptophan-degrading enzyme, plays a key role in the immunomodulatory effects on several types of immune cells. Originally known for its regulatory function during pregnancy and chronic inflammation in tumorigenesis, the activity of IDO1 seems to modify the inflammatory state of infectious diseases. The pathophysiologic activity of L-tryptophan metabolites, kynurenines, is well recognized. Therefore, an understanding of the regulation of IDO1 and the subsequent biochemical reactions is essential for the design of therapeutic strategies in certain immune diseases. In this paper, current knowledge about the role of IDO1 and its metabolites during various infectious diseases is presented. Particularly, the regulation of type I interferons (IFNs) production via IDO1 in virus infection is discussed. This paper offers insights into new therapeutic strategies in the modulation of viral infection and several immune-related disorders.
机译：L-色氨酸降解酶吲哚胺2,3-二加氧酶1（IDO1）在对几种类型免疫细胞的免疫调节作用中起着关键作用。 IDO1的活性最初以其在怀孕期间的调节功能和肿瘤发生中的慢性炎症而著称，它的活性似乎改变了传染病的炎症状态。 L-色氨酸代谢产物犬尿氨酸的病理生理活性已得到公认。因此，了解IDO1的调控和随后的生化反应对于设计某些免疫疾病的治疗策略至关重要。本文介绍了有关IDO1及其代谢物在各种传染病中的作用的最新知识。特别是，讨论了在病毒感染中通过IDO1调节I型干扰素（IFN）的产生。本文提供了对调节病毒感染和几种免疫相关疾病的新治疗策略的见解。

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