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首页> 外文期刊>Medical science monitor : >Fine-structure of the transition from the sclera to the corneoscleral trabeculum in open-angle glaucoma
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Fine-structure of the transition from the sclera to the corneoscleral trabeculum in open-angle glaucoma

机译：开角型青光眼从巩膜向角膜巩膜小梁过渡的精细结构

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Background:The fine structure of the connective tissue constituents of the transition from the sclera to the corneoscleral trabeculum was studied with transmission electron microscopy in open-angle glaucoma.Material/Methods: 29 cases were investigated. The age of the patients ranged between 50 and 85 years, the glaucoma has lasted from 2 to 30 years. The specimens were taken during trabeculectomy after previous local drug treatment and/or laser and surgical interventions. The normal material derived from eyes enucleated because of intraocular tumours, without intraocular pressure elevation.The specimens were investigated with transmission electron microscopy.Results: The irregular scleral fibre system gradually arranged into bundles. The bundles were getting finer and finer, and next mixed with the tissue elements of the cornea, chiefly with those of Descemet's membrane. Then the characteristic fourlayered structure of the trabecular bundles developed. These considerable tissue changes were obviously the morphologic basis of the peculiar function of the trabecular meshwork. In the sclera essential pathologic changes could not be demonstrated during the progression of the disease. In the transitional area, however, according to the change of the tissue structure, the quantity of the pathologic alterations gradually increased. In the fully developed trabecular bundles all the pathologic alterations already known in open-angle glaucoma could be detected. This tendency to develop alterations, however, could be recognized in other types of glaucoma, too.Conclusions: The data on the alterations in the transitional zone from the sclera to the corneoscleral trabeculum may add further information on the sequence of the development of alterations of the morphologic changes found in open-angle glaucoma. These may be similar in morphologic features to those found as age-related changes.
机译：背景：透射电镜观察了角膜青光眼从巩膜向角巩膜小梁过渡的结缔组织成分的精细结构。材料/方法：29例。患者的年龄在50至85岁之间，青光眼持续2至30岁。在先前的局部药物治疗和/或激光和外科手术干预后的小梁切除术中采集标本。正常物质来源于眼球，因眼内肿瘤摘除，无眼内压升高。标本用透射电镜观察。结果：不规则巩膜纤维系统逐渐排列成束。束变得越来越细，然后与角膜的组织成分混合，主要是与Descemet膜的组织成分混合。然后，发展了小梁束的特征性四层结构。这些明显的组织变化显然是小梁网特殊功能的形态学基础。在巩膜中，疾病进展期间无法显示出必要的病理变化。然而，在过渡区域，根据组织结构的变化，病理改变的数量逐渐增加。在完全发育的小梁束中，可以检测到开角型青光眼中所有已知的病理改变。结论：从巩膜到角膜巩膜小梁过渡区的改变数据可能会增加关于青光眼改变发生顺序的信息。在开角型青光眼中发现的形态变化。这些在形态特征上可能与与年龄相关的变化相似。

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