Reduction of apoptosis of in vitro cultured peripheral blood lymphocytes of HIV positive individuals by thymocartin

Be?la Szende; Attila Horva?th; Ka?roly Nagy; J?ozsef Bocsi; Ilona Kovalszky; ?Eva Barab?as

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Reduction of apoptosis of in vitro cultured peripheral blood lymphocytes of HIV positive individuals by thymocartin

机译：胸腺肽减少HIV阳性个体体外培养的外周血淋巴细胞凋亡

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Background: Apoptotic (natural or programmed) cell death of lymphocytes contributes to an immune decline of HIV-infected persons. Active fragments of thymopoietin may reduce apoptosis and slow down this progress of immune decline.Material/Methods: In vitro studies were performed in order to investigate the apoptosis-reducing effect of a new active thymopoietin fragment, Thymocartin (Arg-Lys-Asp-Val). Separated peripheral blood lymphocytes of 10 asymptomatic HIV-positive and 7 HIV-negative persons were cultured. Unstimulated, IL-2-stimulated and IL-2-stimulated plus 0.1 and 0.001 μg/ml Thymocartin-treated cells were investigated for apoptosis by morphological (HE, Apop-Tag), flow cytometric and agarose DNA fragmentation methods.Results: Unstimulated lymphocytes of HIV-positive persons showed higher apoptotic activity than those of HIV-negative persons. IL-2-stimulation increased the apoptotic rate in 7 HIV-positive and 1 HIV-negative individuals. Thymocartin reduced the apoptotic activity in 8 HIV-positive and 1 HIV-negative case.Conclusions: Thymocartin reduces the apoptotic activity in lymphocytes of HIV-positive patients in vitro. This compound may have the same effect in vivo and may prolong the asymptomatic period of HIV-infected patients.

机译：背景：淋巴细胞的凋亡（天然或程序性）死亡导致HIV感染者的免疫功能下降。胸腺生成素的活性片段可能减少细胞凋亡并减慢免疫下降的进程。材料/方法：进行了体外研究，以研究新的胸腺生成素的活性片段胸腺肽（Arg-Lys-Asp-Val）的凋亡减少作用。）。培养分离的10例无症状HIV阳性和7例HIV阴性的人的外周血淋巴细胞。通过形态学（HE，Apop-Tag），流式细胞术和琼脂糖DNA片段化方法研究未刺激，IL-2刺激和IL-2刺激以及0.1和0.001μg/ ml胸腺肽处理的细胞的凋亡情况。结果：未刺激的淋巴细胞艾滋病毒阳性者的凋亡活性高于艾滋病毒阴性者。 IL-2刺激增加了7个HIV阳性和1个HIV阴性个体的凋亡率。胸腺肽降低了8例HIV阳性和1例HIV阴性的细胞的凋亡活性。结论：胸腺肽降低了HIV阳性患者的淋巴细胞的凋亡活性。该化合物在体内可能具有相同的作用，并可能延长HIV感染患者的无症状期。

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《Medical science monitor :》 |1997年第2期|共4页
作者
Be?la Szende; Attila Horva?th; Ka?roly Nagy; J?ozsef Bocsi; Ilona Kovalszky; ?Eva Barab?as;
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中图分类医药、卫生;
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Reduction of apoptosis of in vitro cultured peripheral blood lymphocytes of HIV positive individuals by thymocartin

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