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Parental consanguinity and risk of breast cancer: A population-based case-control study

机译：父母的血缘关系和患乳腺癌的风险：一项基于人群的病例对照研究

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Background: An estimated 600 million people in the world have consanguineousparents. The effect of consanguinity on the risk of breast cancer is uncertain. The objective of thiscase-control study was to examine whether parental consanguinity and different levels of inbreeding affectthe risk and pathology characteristics of breast cancer. Material/Methods: Over a 36-month period, consecutivefemale breast cancer patients were recruited in the main cancer hospital in the United Arab Emirates.All were locally born Arabs with a tissue diagnosis of breast cancer. The controls were locally bornArabs without breast cancer matched to cases by sex, age, and residence. The coefficient of inbreeding(F) of both groups was determined from information they provided about their parents' kinship. Results:The mean age of the 72 patients and 187 controls was 48.6 years (range: 25-86) and 48.5 years (range:25-82), respectively (P=0.46). Consanguinity rates of the patients and controls were 29.2% and 28.9%(P=0.96) and the coefficients of inbreeding were 0.0117 and 0.0167 (P=0.21), respectively. More closelyinbred women (F>/=0.0625) were less frequent among patients than controls, but the difference was notstatistically significant (P=0.12). The rates of pathological stage of disease, tumor histologies, andtumor grades were similar between more and less inbred patients. Conclusions: Parental consanguinityin Arabs, even when a marriage is between first cousins or double first cousins, was not associated withan altered risk of breast cancer.
机译：背景：全世界估计有6亿人有近亲。血缘关系对乳腺癌风险的影响尚不确定。本病例对照研究的目的是检查父母的血缘关系和近亲繁殖水平是否会影响乳腺癌的风险和病理特征。资料/方法：在36个月的时间里，从阿拉伯联合酋长国的主要癌症医院招募了连续的女性乳腺癌患者，所有患者均为当地出生的阿拉伯人，具有乳腺癌的组织诊断。对照组是当地出生的无乳腺癌的阿拉伯人，按性别，年龄和居住情况进行匹配。两组的近交系数（F）是根据他们提供的有关父母亲属的信息确定的。结果：72例患者和187例对照者的平均年龄分别为48.6岁（范围：25-86）和48.5岁（范围：25-82）（P = 0.46）。患者和对照组的血缘发生率分别为29.2％和28.9％（P = 0.96），近交系数分别为0.0117和0.0167（P = 0.21）。患者中近亲女性（F> / = 0.0625）的频率低于对照组，但差异无统计学意义（P = 0.12）。近交患者的病态病理分期，肿瘤组织学和肿瘤等级的发生率相似。结论：阿拉伯人的父母血缘关系，即使是在表亲或双表亲之间结婚，也与乳腺癌风险改变无关。

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