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Evaluation of lipid peroxidation, oxidant/antioxidantstatus, and serum nitric oxide levels in alopecia areata

机译:斑秃中脂质过氧化,氧化剂/抗氧化剂状态和血清一氧化氮水平的评估

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SummaryBackground: The pathophysiology of alopecia areata (AA) has not been clearly defi ned; however, it appears as a tissue-restricted autoimmune disease mediated by T lymphocytes. Immunohistochemical studies have shown peri- and infra-follicular infl ammatory infi ltrate which damages hair follicles. We analyzedthe role of lipid peroxidation and oxidant-antioxidant enzymes in the pathogenesis of AA.Material/Methods: Twenty-four patients with AA and 20 age- and sex-matched healthy controls were enrolled in this study. We analyzed serum levels of malondialdehyde (MDA) and nitric oxide (NO) and the serum activities of superoxide dismutase (SOD) and xanthine oxidase (XO) in patients with AA and control subjects.Results: The levels of MDA and NO (nitriteitrate) and the activity of XO in serum of patients with AA (0.76±0.34 nmol/ml, 14.88±6.40 nmol/ml, and 0.34±0.10 U/ml, respectively) were signifi cantlyhigher than those of controls (0.35±0.09 nmol/ml, 10.71±1.75 nmol/ml, 0.11±0.03 U/ml; p
机译:总结背景:斑秃的病理生理学尚未明确。然而,它表现为由T淋巴细胞介导的组织限制性自身免疫病。免疫组织化学研究表明,囊泡周围和囊泡下的通气性渗透液会损害毛囊。我们分析了脂质过氧化和抗氧化酶在AA发病机理中的作用。材料/方法:本研究招募了24例AA患者和20位年龄和性别相匹配的健康对照。我们分析了AA和对照组受试者的丙二醛(MDA)和一氧化氮(NO)的血清水平以及超氧化物歧化酶(SOD)和黄嘌呤氧化酶(XO)的血清活性。结果:MDA和NO的水平硝酸盐(AA)和AA患者血清XO活性(分别为0.76±0.34 nmol / ml,14.88±6.40 nmol / ml和0.34±0.10 U / ml)显着高于对照组(0.35±0.09 nmol) /ml,10.71±1.75 nmol / ml,0.11±0.03 U / ml; p

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