...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Medical science monitor : >Reliability of interleukin-6 and interleukin-8 in distinguishing between infectious and non-infectious respiratory disorders in neonates
【24h】

Reliability of interleukin-6 and interleukin-8 in distinguishing between infectious and non-infectious respiratory disorders in neonates

机译：白细胞介素6和白细胞介素8在区分新生儿感染性和非感染性呼吸系统疾病中的可靠性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Interleukin-6 and interleukin-8 are mediators of inflammatory process with high diagnostic value in early-onset neonatal sepsis. Their role in localized infection is much less known. Therefore the aim of our study was to investigate the reliability of interleukin-6 and interleukin-8 in distinguishing between infectious and non-infectious respiratory disorders in neonates.Material/Methods: The prospective study was conducted in 76 newborns. In 49 of them clinical signs of respiratory distress were present at birth, and 27 served as control group.Results: Mean value ±SEM of interleukin-6 in newborns with pneumonia was 43.11±10.37 pg/ml and in non-infected 10.48±1.53 pg/ml; p=0.000. For interleukin-8 mean value ±SEM in newborns with pneumonia was 346.75±36.84 pg/ml, andin non-infected 46.56±6.55 pg/ml; p=0.011. Comparing separately the groups of neonates with respiratory distress syndrome (RDS), transient tachypnoe of the newborn (TTN) and healthy ones with newborns with pneumonia we found out statistically significant differences in mean values of interleukin-6 and interleukin-8 but no other markers. There were no statistically significant differences in none of the parameters between the groups of neonates with RDS, TTN or healthy ones. Sensitivity and specificity for interleukin-6 level ?15.4pg/mL were 88.9% and 93.0% respectively, and area under the curve (AUC) 0.92 and for interleukin-8 level ?44pg/mL were 83.3%, 70.2%, 0.83. respectively. Diagnostic value of interleukin-6 and interleukin-8 was better than other routinely used markers of infection.Conclusions: Interleukin-6 and interleukin-8 are good diagnostic markers of early-onset neonatal pneumonia. Their sensitivity and interleukin’s-6 specificity exceed routinely used indices. They distinguish well between children with intrauterine pneumonia and respiratory disorders of non-infectious origin.
机译：背景：白细胞介素6和白细胞介素8是炎性过程的介质，对早期发作的新生儿败血症具有较高的诊断价值。它们在局部感染中的作用还鲜为人知。因此，本研究的目的是探讨白细胞介素6和白细胞介素8在区分新生儿感染性和非感染性呼吸系统疾病中的可靠性。材料/方法：前瞻性研究在76例新生儿中进行。其中49例在出生时出现呼吸窘迫的临床体征，而27例作为对照组。结果：新生儿肺炎中白细胞介素6的平均值±SEM为43.11±10.37 pg / ml，未感染者为10.48±1.53。 pg / ml; p ＝ 0.000。新生儿肺炎的白细胞介素8平均值±SEM为346.75±36.84 pg / ml，未感染新生儿为46.56±6.55 pg / ml。 p ＝ 0.011。分别比较新生儿呼吸窘迫综合征（RDS），新生儿短暂性呼吸暂停（TTN）和健康人群与肺炎新生儿的分组，我们发现白介素6和白介素8的平均值存在统计学差异，但没有其他标志物。在具有RDS，TTN或健康婴儿的新生儿组之间，任何参数都没有统计学上的显着差异。白细胞介素6水平≥15.4pg/ mL的敏感性和特异性分别为88.9％和93.0％，曲线下面积（AUC）为0.92和白细胞介素8水平≥44pg/ mL的敏感性为83.3％，70.2％，0.83。分别。结论：白细胞介素-6和白细胞介素8是新生儿早发性肺炎的良好诊断指标。白细胞介素6和白细胞介素8的诊断价值优于其他常用的感染指标。它们的敏感性和白介素-6特异性超过了常规指标。他们在子宫内肺炎和非感染性呼吸道疾病患儿之间有很好的区分。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号