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首页> 外文期刊>Medical science monitor : >The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-L-arginine methyl ester and L-arginine.
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The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-L-arginine methyl ester and L-arginine.

机译：胃五肽BPC 157对小鼠急性和慢性乙醇给药的影响。 N（G）-硝基-L-精氨酸甲酯和L-精氨酸的作用。

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BACKGROUND: Alcohol disturbances, NO stimulation (by the NO-precursor L-arginine), and/or NO-synthesis blockade (by N(G)-nitro-L-arginine methyl ester, i.e. L-NAME) were challenged with stable gastric pentadecapeptide BPC 157, which inhibits both acute alcohol intoxication and alcohol withdrawal symptoms. MATERIAL/METHODS: Mice received intraperitoneally (i.p.) BPC 157 (10 microg/kg), L-NAME (10 mg/kg), and L-arginine (400 mg/kg), alone or in combination, 5 minutes before or after acute ethanol (4 g/kg i.p.) intoxication or after 0, 3, or 7 hours of withdrawal after drinking 20% alcohol for 13 days. RESULTS: BPC 157 rapidly opposes the strongest disturbance presentations in acute intoxication (sustained ethanol anesthesia, complete loss of righting reflex, no reaction to external stimuli, hypothermia, 25% mortality) and withdrawal (prominent seizures). NO-agents: Aggravation of acute alcohol intoxication and opposition to withdrawal are common, but the later intervals affected by L-arginine and the action throughout the experiment by L-NAME are distinctive. Given together, L-arginine and L-NAME counteract each other, while either the "L-NAME presentation" (acute intoxication) or the "L-arginine presentation" (withdrawal) predominates. BPC157+NO-agent: In acute intoxication (L-NAME predominating in NO-system functioning to aggravate intoxication), both BPC157+L-NAME and BPC157+L-arginine follow the presentation of L-NAME, but without worsened mortality. In withdrawal (L-arginine predominating in NO-system functioning to oppose disturbance symptoms), BPC157+L-NAME follows the presentation of L-NAME, while BPC 157+L-arginine imitates that of L-arginine. CONCLUSIONS: The relationships among pentadecapeptide BPC 157, the NO-system, acute alcohol intoxication, and opposed withdrawal may be important, presenting pentadecapeptide BPC 157 as a suitable alcohol antagonist.
机译：背景：酒精干扰，NO刺激（通过NO前体L-精氨酸）和/或NO合成阻滞（通过N（G）-硝基-L-精氨酸甲酯，即L-NAME）受到稳定的胃液的攻击五肽肽BPC 157，可抑制急性酒精中毒和戒酒症状。材料/方法：小鼠腹膜内（ip）BPC 157（10 microg / kg），L-NAME（10 mg / kg）和L-精氨酸（400 mg / kg）单独或联合给药，在腹腔注射之前或之后5分钟急性乙醇（4 g / kg ip）中毒，或在饮用20％酒精13天后停药0、3或7小时。结果：BPC 157在急性中毒（持续的乙醇麻醉，对正反射完全丧失，对外界刺激无反应，体温过低，死亡率25％）和停药（癫痫发作）中最强烈的干扰表现出了强烈反对。 NO剂：急性酒精中毒加重和对戒断的抵抗是很常见的，但后来受到L-精氨酸影响的间隔和L-NAME在整个实验中的作用是独特的。综上所述，L-精氨酸和L-NAME相互抵消，而“ L-NAME呈递”（急性中毒）或“ L-精氨酸呈递”（戒断）占主导。 BPC157 + NO剂：在急性中毒（在NO系统中以L-NAME为主，加剧中毒）中，BPC157 + L-NAME和BPC157 + L-精氨酸均遵循L-NAME的症状，但死亡率没有恶化。在戒断中（L-精氨酸在NO系统中起主要作用以抵抗干扰症状），BPC157 + L-NAME遵循L-NAME的出现，而BPC 157 + L-精氨酸模仿L-精氨酸。结论：五肽BPC 157，NO系统，急性酒精中毒和相对戒断之间的关系可能很重要，提出五肽BPC 157是合适的酒精拮抗剂。

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