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首页> 外文期刊>Medical science monitor : >Constraint-Induced Aphasia Therapy for Treatment of Chronic Post-Stroke Aphasia: A Randomized, Blinded, Controlled Pilot Trial
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Constraint-Induced Aphasia Therapy for Treatment of Chronic Post-Stroke Aphasia: A Randomized, Blinded, Controlled Pilot Trial

机译：约束诱导的失语症疗法治疗慢性中风后失语症：随机，盲，对照的试验性试验。

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BACKGROUND To provide a preliminary estimate of efficacy of constraint-induced aphasia therapy (CIAT) when compared to no-intervention in patients with chronic (>1 year) post-stroke aphasia in order to plan an appropriately powered randomized controlled trial (RCT).? MATERIAL AND METHODS We conducted a pilot single-blinded RCT. ?24 patients were randomized: 14 to CIAT and 10 to no-intervention.? CIAT groups received up to 4 hours/day of intervention for 10 consecutive business days (40 hours or therapy).? Outcomes were assessed within 1 week of intervention and at 1 and 12 weeks after intervention and included several linguistic measures and a measure of overall subjective communication abilities (mini-Communicative Abilities Log (mini-CAL)).? Clinicians treating patients (CIAT group) did not communicate with other team members to maintain blinding and the testing team members were blinded to treatment group assignment.? RESULTS Overall, the results of this pilot RCT support the results of previous observational studies that CIAT may lead to improvements in linguistic abilities.? At 12 weeks, the treatment group reported better subjective communication abilities (mini-CAL) than the no-intervention group (p=0.019).? Other measures trended towards better performance in the CIAT group. CONCLUSIONS In this pilot RCT intensive language therapy led to an improvement in subjective language abilities.? The effects demonstrated allow the design of a definitive trial of CIAT in patients with a variety of post-stroke aphasia types.? In addition, our experiences have identified important considerations for designing subsequent trial(s) of CIAT or other interventions for post-stroke aphasia.
机译：背景技术为对慢性卒中后失语症的慢性（> 1年）患者进行无干预治疗，与无干预相比较，提供初步估计的约束诱导的失语治疗（CIAT）的疗效，以计划进行适当的随机对照试验（RCT）。 ？材料与方法我们进行了单盲RCT试验。随机分配24例患者：14例接受CIAT，10例不进行干预。 CIAT组连续10个工作日（每天40小时或治疗）每天最多接受4个小时的干预。在干预的1周内以及干预后的1周和12周对结果进行评估，包括几种语言学测量和整体主观交流能力的测量（迷你沟通能力记录（mini-CAL））。治疗患者的临床医生（CIAT组）没有与其他团队成员进行沟通以保持盲目性，并且测试团队成员对盲目分配了盲目性。结果总的来说，该试验性RCT的结果支持了以前的观察性研究的结果，即CIAT可能导致语言能力的提高。在12周时，治疗组报告的主观交流能力（mini-CAL）比无干预组更好（p = 0.019）。 CIAT组还采取了其他措施来提高绩效。结论在该RCT试点中，强化语言治疗导致主观语言能力的提高。所显示的效果允许针对各种中风后失语症类型的患者进行CIAT的明确试验设计。此外，我们的经验已经确定了设计CIAT的后续试验或中风后失语症的其他干预措施的重要考虑因素。

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