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首页> 外文期刊>Medical science monitor : >Analysis of bioelectrical cerebral function based on visual and brain stem auditory evoked potentials in patients with chronic renal failure
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Analysis of bioelectrical cerebral function based on visual and brain stem auditory evoked potentials in patients with chronic renal failure

机译：基于视觉和脑干听觉诱发电位的慢性肾功能衰竭患者生物电脑功能分析

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The aim of the study was assessment of visual (VEPs) and brain stem auditory evoked potentials (BAEPs) in patients dialysed due to chronic renal failure in order to evaluate the clinical usefulness of this method. In 50 patients (19 female, 31 male), aged 28-73 (mean 50) dialysed because of chronic renal failure, VEPs and BAEPs were performed. In 12 patients no abnormalities were found in neurologic examination; 23 displayed polyneuropathy of minor degree; 28 showed symptoms of minimal CNS lesions. VEPs were recorded over visual cortex, while right and left eye were stimulated subsequently with the reversal checkerboard pattern. Latency and amplitude of visual evoked response (P100) were estimated. BAEPs were recorded over the mastoid. Latencies of components I-V of brain stem auditory response and interpeak latencies I-III, III-V, I-V were estimated. The results were compared to the data obtained in 50 age-matched controls and statistically analysed by means of Student's t-test. Abnormal VEPs (mean latencies significantly longer in comparison with the control group) and/or BAEPs (significantly prolonged latencies of particular components and interlatencies I-III, III-V, I-V) were recorded in 32 cases (64%). The authors attribute this high percentage of abnormal evoked potentials in dialysed patients to the presence - apart from renal failure - of other diseases affecting CNS (diabetes, collagenoses, hypertension). Abnormal evoked potentials (EP) were found in patients with symptoms of CNS damage, as well as without them. No correlation was found between pathologic EPs and duration of dialysis, degree of anaemia and serum levels of urea and creatinin. Evoked potentials abnormalities did not depend on EEG changes. EP study in patients with chronic renal failure, especially without clinical symptoms of CNS damage may be helpful in prognosis and monitoring of the course of the disease and the results of treatment.
机译：该研究的目的是评估因慢性肾功能衰竭而透析的患者的视觉（VEP）和脑干听觉诱发电位（BAEP），以评估该方法的临床实用性。在50位因慢性肾衰竭而透析的28-73岁（平均50岁）的患者中（19位女性，31位男性），进行了VEP和BAEP。 12例患者的神经系统检查未发现异常。 23例表现为轻度多发性神经病; 28例显示中枢神经系统病变最小的症状。在视觉皮层上记录VEP，而随后用反转棋盘图案刺激右眼和左眼。估计了视觉诱发反应的潜伏期和幅度（P100）。在乳突上记录了BAEP。估计了脑干听觉反应的组分I-V的潜伏期和峰间潜伏期I-III，III-V，I-V。将结果与在50个年龄匹配的对照中获得的数据进行比较，并通过Student t检验进行统计分析。记录了32例（64％）的VEP异常（与对照组相比，平均潜伏期明显更长）和/或BAEP（特定成分的潜伏期显着延长，以及I-III，III-V，I-V的潜伏期）。作者认为，透析患者中​​较高的异常诱发电位是肾功能以外的其他影响中枢神经系统疾病（糖尿病，胶原蛋白，高血压）的原因。有中枢神经系统损害症状的患者以及没有中枢神经系统损害的患者均发现异常诱发电位（EP）。在病理性EP与透析时间，贫血程度以及尿素和肌酐的血清水平之间没有相关性。诱发电位异常并不取决于脑电图的变化。对患有慢性肾功能衰竭的患者进行EP研究，尤其是没有中枢神经系统损害的临床症状的EP研究，可能有助于预后和监测病程以及治疗结果。

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