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首页> 外文期刊>Medical Science Monitor Basic Research >LYN, a Key Gene From Bioinformatics Analysis, Contributes to Development and Progression of Esophageal Adenocarcinoma
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LYN, a Key Gene From Bioinformatics Analysis, Contributes to Development and Progression of Esophageal Adenocarcinoma

机译：LYN是生物信息学分析的关键基因，有助于食管腺癌的发展和进展

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BACKGROUND Esophageal adenocarcinoma is a lethal malignancy whose incidence is rapidly growing in recent years. Previous reports suggested that Barrett’s esophagus (BE), which is represented by metaplasia-dysplasia-carcinoma transition, is regarded as the premalignant lesion of esophageal neoplasm. However, our knowledge about the development of esophageal adenocarcinoma is still very limited. MATERIAL AND METHODS In order to acquire better understanding about the pathological mechanisms in this field, we obtained gene profiling data on BE, esophageal adenocarcinoma patients, and normal controls from the Gene Expression Omnibus (GEO) database. Bioinformatics analyses, including Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, were conducted. RESULTS Our results revealed that several pathways, such as the wound healing, complement, and coagulation pathways, were closely correlated with cancer development and progression. The mitogen-activated protein kinase (MAPK) pathway was discovered to be responsible for the predisposition stage of cancer; while response to stress, cytokine-cytokine receptor interaction, nod-like receptor signaling pathway, and ECM-receptor interaction were chief contributors of cancer progression. More importantly, we discovered in this study that LYN was a critical gene. It was found to be the key nodule of several significant biological networks, which suggests its close correlation with cancer initiation and progression. CONCLUSIONS These results provided more information on the mechanisms of esophageal adenocarcinoma, which enlightened our way to the clinical discovery of novel therapeutic makers for conquering esophageal cancer. Keywords: esophageal adenocarcinoma; LYN; Go analysis; KEGG pathway.
机译：背景技术食管腺癌是一种致命的恶性肿瘤，近年来其发病率迅速增长。先前的报道表明，以化生-不典型增生-癌变为代表的巴雷特食管（BE）被认为是食道肿瘤的癌前病变。但是，我们对食管腺癌发展的认识仍然非常有限。材料和方法为了更好地了解该领域的病理机制，我们从基因表达综合（GEO）数据库中获得了BE，食管腺癌患者和正常对照的基因谱数据。进行了生物信息学分析，包括基因本体论（GO）分析和《京都议定书》中的基因与基因组百科全书（KEGG）途径分析。结果我们的结果表明，几种途径，例如伤口愈合，补体和凝血途径，与癌症的发展和进展密切相关。发现有丝分裂原激活的蛋白激酶（MAPK）通路与癌症的易感阶段有关。而对压力的反应，细胞因子-细胞因子受体的相互作用，nod-like受体信号通路和ECM-受体的相互作用是癌症进展的主要因素。更重要的是，我们在这项研究中发现LYN是关键基因。人们发现它是几个重要生物学网络的关键结节，这表明它与癌症的发生和发展密切相关。结论这些结果为食管腺癌的发病机理提供了更多的信息，为我们探索新型治疗剂治疗食管癌的临床方法提供了启示。关键词：食管腺癌; LYN;去分析; KEGG途径。

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