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Collagen: A potential factor involved in the pathogenesis of glaucoma

机译：胶原蛋白：与青光眼发病有关的潜在因素

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Numerous studies have been completed on glaucoma pathogenesis. However, the potential and controversial interaction between ocular biomechanical properties and the glaucomatous diseases process has received much more attention recently. Previous studies have found that collagen tissues gain mutation change in glaucoma patients. This study was conducted to determine the role of collagen in the biomechanics of glaucoma in humans. Its changes may be the result of mechanical modifications brought on by intraocular pressure (IOP) fluctuations. More importantly, biomechanics and genetic evidence indicate that the mutation of collagen may play a role in the process of glaucoma. Alteration of collagen in the outflow pathway may alter mechanical tissue characteristics and a concomitant increase of aqueous humor outflow resistance and elevation of IOP. The variations of collagen, leading to inter-individual differences in scleral and lamina cribrosa properties, result in different susceptibility of individuals to elevated IOP. Therefore, this study hypothesized that collagen mutations may be an original cause of glaucoma.
机译：关于青光眼发病机理的许多研究已经完成。然而，眼生物力学特性和青光眼疾病过程之间潜在的和有争议的相互作用最近受到了越来越多的关注。先前的研究发现，青光眼患者的胶原组织获得突变。进行这项研究是为了确定胶原蛋白在人类青光眼的生物力学中的作用。其变化可能是眼内压（IOP）波动引起的机械改变的结果。更重要的是，生物力学和遗传学证据表明胶原蛋白的突变可能在青光眼的过程中起作用。胶原蛋白在流出途径中的改变可能会改变机械组织的特性，并伴随房水流出阻力的增加和眼压的升高。胶原蛋白的变化导致个体之间的巩膜和筛板特性差异，导致个体对IOP升高的敏感性不同。因此，这项研究假设胶原蛋白突变可能是青光眼的原始原因。

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