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Botulinum toxin A injection into the anterior belly of the digastric muscle increased the posterior width of the maxillary arch in developing rats

机译:向发育中的大鼠的胃前肌腹中注射肉毒杆菌毒素A会增加上颌弓的后宽度

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Abstract BackgroundThe purpose of this study was to evaluate the effects of botulinum toxin A (BTX) injection into the anterior belly of the digastric muscle on a growing rat.MethodsTen Sprague Dawley rats were used in this study. When the rats were 13?days old, 0.5?units of BTX was injected into the anterior belly of the digastric muscle for the experimental group ( n =?5). For the control, the same volume of normal saline was injected ( n =?5). The rats were sacrificed at 60?days old, and the skulls were harvested for micro-computed tomography (μCT) analysis.ResultsIn anthropometric analysis, the zygomatic arch and mandibular bi-condylar width were significantly lower in the experimental group than those in the control group ( P =?0.025 and 0.027, respectively). The maxillary point width was significantly higher in the experimental group than that in the control group ( P =?0.020).ConclusionBTX injection into the anterior belly of the digastric muscle had effects on the maxillofacial bony width in growing rats.
机译:摘要背景:本研究的目的是评估向生长中的大鼠的腓肠肌前腹中注射肉毒杆菌毒素A(BTX)的效果。方法采用十只Sprague Dawley大鼠。实验组在大鼠13天大时,将其0.5单位的BTX注入到胃前肌中(n =?5)。作为对照,注射了相同体积的生理盐水(n =?5)。在60天大时处死大鼠,并收集头骨进行显微计算机断层扫描(μCT)分析。结果在人体测量学分析中,实验组的man弓和下颌双-宽度明显低于对照组。组(分别为P =?0.025和0.027)。实验组上颌骨点宽明显高于对照组(P =?0.020)。结论在成年大鼠的腓肠肌前腹中注射BTX对上颌骨宽度有影响。

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