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Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors

机译：饮用富含氢的水对肝肿瘤放疗患者生活质量的影响

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Background Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflammation in tissues. This study examined whether hydrogen treatment, in the form of hydrogen-supplemented water, improved QOL in patients receiving radiotherapy. Methods A randomized, placebo-controlled study was performed to evaluate the effects of drinking hydrogen-rich water on 49 patients receiving radiotherapy for malignant liver tumors. Hydrogen-rich water was produced by placing a metallic magnesium stick into drinking water (final hydrogen concentration; 0.55~0.65 mM). The Korean version of the European Organization for Research and Treatment of Cancer's QLQ-C30 instrument was used to evaluate global health status and QOL. The concentration of derivatives of reactive oxidative metabolites and biological antioxidant power in the peripheral blood were assessed. Results The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. QOL scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water compared to patients receiving placebo water. There was no difference in tumor response to radiotherapy between the two groups. Conclusions Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects.
机译：背景技术接受放射疗法的癌症患者经常会感到疲劳和生活质量（QOL）受损。放疗的许多副作用被认为与氧化应激和炎症增加有关，这是由于放疗期间产生了活性氧。氢可以作为治疗性医疗气体施用，具有抗氧化特性，并可以减少组织中的炎症。这项研究检查了以氢气补充水的形式进行的氢气治疗是否可以改善接受放射治疗的患者的生活质量。方法进行了一项随机，安慰剂对照研究，以评估饮用富含氢的水对49例恶性肝肿瘤放疗患者的影响。通过将金属镁棒放入饮用水中（最终氢浓度; 0.55〜0.65 mM）来生产富氢水。欧洲癌症研究与治疗组织的韩文版QLQ-C30仪器用于评估全球健康状况和QOL。评估外周血中反应性氧化代谢产物的衍生物浓度和生物抗氧化能力。结果连续6周食用富含氢的水可减少血液中的活性氧代谢产物并保持血液氧化的潜力。与接受安慰剂水的患者相比，接受富氢水治疗的患者在放疗期间的生活质量得分显着提高。两组对放疗的肿瘤反应无差异。结论每天摄入富含氢的水是一种潜在的，新颖的治疗策略，可以改善辐射暴露后的生活质量。消耗富氢水可减少对辐射引起的氧化应激的生物反应，而不会影响抗肿瘤作用。

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