• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Medical Gas Research >Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp /NDmcr rat - a metabolic syndrome rat model
【24h】

Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp /NDmcr rat - a metabolic syndrome rat model

机译：富氢水对SHR.Cg-Leprcp / NDmcr大鼠（代谢综合征大鼠模型）异常的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome. Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in the metabolic syndrome rat model, SHR.Cg-Leprcp/NDmcr (SHR-cp). Methods Male SHR-cp rats (5 weeks old) were divided into 2 groups: an HRW group was given oral HRW for 16 weeks, and a control group was given distilled water. At the end of the experiment, each rat was placed in a metabolic cage for 24 h, fasted for 12 h, and anesthetized; the blood and kidneys were then collected. Results Sixteen weeks after HRW administration, the water intake and urine flow measured in the metabolic cages were significantly higher in the HRW group than in the control group. The urinary ratio of albumin to creatinine was significantly lower and creatinine clearance was higher in the HRW group than in the control group. After the 12-h fast, plasma urea nitrogen and creatinine in the HRW group were significantly lower than in the control group. The plasma total antioxidant capacity was significantly higher in the HRW group than in the control group. The glomerulosclerosis score for the HRW group was significantly lower than in the control group, and a significantly positive correlation was observed between this score and plasma urea nitrogen levels. Conclusion The present findings suggest that HRW conferred significant benefits against abnormalities in the metabolic syndrome model rats, at least by preventing and ameliorating glomerulosclerosis and creatinine clearance.
机译：背景氢（H 2 ）是一种有效的自由基清除剂，可选择性还原羟基自由基，后者是活性氧（ROS）最具细胞毒性的物质。氧自由基的增加引起氧化应激，已知其参与代谢综合征的发展。因此，我们研究了富氢水（HRW）是否会影响代谢综合征大鼠模型SHR.Cg-Lepr cp / NDmcr（SHR-cp）中的代谢异常。方法将5周大的雄性SHR-cp大鼠分为2组：HRW组口服HRW 16周，对照组给予蒸馏水。实验结束时，将每只大鼠置于代谢笼中24 h，禁食12 h，然后麻醉。然后收集血液和肾脏。结果施用HRW后16周，HRW组代谢笼中的进水量和尿流量显着高于对照组。与对照组相比，HRW组白蛋白与肌酐的尿比明显降低，肌酐清除率更高。禁食12小时后，HRW组的血浆尿素氮和肌酐显着低于对照组。 HRW组的血浆总抗氧化能力显着高于对照组。 HRW组的肾小球硬化评分显着低于对照组，并且该评分与血浆尿素氮水平之间存在显着正相关。结论目前的发现表明，至少通过预防和改善肾小球硬化和肌酐清除率，HRW可以明显改善代谢综合征模型大鼠的异常状况。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号