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A hypothesis on biological protection from space radiation through the use of new therapeutic gases as medical counter measures

机译：关于通过使用新的治疗气体作为医学对策来保护生物免受空间辐射的假说

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Radiation exposure to astronauts could be a significant obstacle for long duration manned space exploration because of current uncertainties regarding the extent of biological effects. Furthermore, concepts for protective shielding also pose a technically challenging issue due to the nature of cosmic radiation and current mass and power constraints with modern exploration technology. The concern regarding exposure to cosmic radiation is biological damage that is associated with increased oxidative stress. It is therefore important and would be enabling to mitigate and/or prevent oxidative stress prior to the development of clinical symptoms and disease. This paper hypothesizes a "systems biology" approach in which a combination of chemical and biological mitigation techniques are used conjunctively. It proposes using new, therapeutic, medical gases as chemical radioprotectors for radical scavenging and as biological signaling molecules for management of the body's response to exposure. From reviewing radiochemistry of water, biological effects of CO, H2, NO, and H2S gas, and mechanisms of radiation biology, it can be concluded that this approach may have therapeutic potential for radiation exposure. Furthermore, it also appears to have similar potential for curtailing the pathogenesis of other diseases in which oxidative stress has been implicated including cardiovascular disease, cancer, chronic inflammatory disease, hypertension, ischemia/reperfusion (IR) injury, acute respiratory distress syndrome, Parkinson's and Alzheimer's disease, cataracts, and aging. We envision applying these therapies through inhalation of gas mixtures or ingestion of water with dissolved gases.
机译：由于目前对生物影响程度的不确定性，暴露于宇航员的辐射可能成为长时间载人航天探索的重大障碍。此外，由于宇宙辐射的性质以及现代勘探技术的当前质量和功率限制，保护性屏蔽的概念也带来了技术难题。关于暴露于宇宙辐射的关注是与氧化应激增加相关的生物损伤。因此，重要的是，它将能够在临床症状和疾病发展之前减轻和/或预防氧化应激。本文假设了一种“系统生物学”方法，其中化学和生物缓解技术的组合被结合使用。它提议使用新型的治疗性医学气体作为化学辐射防护剂，以进行自由基清除，并作为生物信号分子来管理人体对暴露的反应。通过回顾水的放射化学，CO，H 2 ，NO和H 2 气体的生物学效应以及放射生物学的机理，可以得出结论，这种方法可能有放射线治疗潜力。此外，它还具有减少其他与氧化应激有关的疾病的发病机理的相似潜力，这些疾病包括心血管疾病，癌症，慢性炎性疾病，高血压，缺血/再灌注（IR）损伤，急性呼吸窘迫综合征，帕金森氏症和老年痴呆症，白内障和衰老。我们设想通过吸入气体混合物或将水与溶解性气体一起摄入来应用这些疗法。

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