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首页> 外文期刊>Medical Gas Research >Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats
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Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats

机译：喝氢气和间歇性暴露于氢气中，但不摄取乳果糖或持续暴露于氢气中，可以预防6-羟多巴胺诱发的帕金森氏病

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Background Lactulose is a synthetic disaccharide that can be catalyzed only by intestinal bacteria in humans and rodents, and a large amount of hydrogen is produced by bacterial catalysis of lactulose. We previously reported marked effects of ad libitum administration of hydrogen water on prevention of a rat model of Parkinson’s disease (PD). Methods End-alveolar breath hydrogen concentrations were measured in 28 healthy subjects and 37 PD patients, as well as in 9 rats after taking hydrogen water or lactulose. Six-hydroxydopamine (6-OHDA)-induced hemi-PD model was stereotactically generated in rats. We compared effects of hydrogen water and lactulose on prevention of PD. We also analyzed effects of continuous and intermittent administration of 2% hydrogen gas. Results Hydrogen water increased breath hydrogen concentrations from 8.6?±?2.1 to 32.6?±?3.3 ppm (mean and SEM, n?=?8) in 10 min in healthy subjects. Lactulose increased breath hydrogen concentrations in 86% of healthy subjects and 59% of PD patients. Compared to monophasic hydrogen increases in 71% of healthy subjects, 32% and 41% of PD patients showed biphasic and no increases, respectively. Lactulose also increased breath hydrogen levels monophasically in 9 rats. Lactulose, however, marginally ameliorated 6-OHDA-induced PD in rats. Continuous administration of 2% hydrogen gas similarly had marginal effects. On the other hand, intermittent administration of 2% hydrogen gas prevented PD in 4 of 6 rats. Conclusions Lack of dose responses of hydrogen and the presence of favorable effects with hydrogen water and intermittent hydrogen gas suggest that signal modulating activities of hydrogen are likely to be instrumental in exerting a protective effect against PD.
机译：背景技术乳果糖是仅人类和啮齿动物中的肠细菌可催化的合成二糖，并且乳果糖的细菌催化产生大量氢。我们之前曾报道过随意使用氢水对预防帕金森氏病（PD）大鼠模型具有显著作用。方法测量28名健康受试者和37名PD患者以及9名服用氢水或乳果糖的大鼠的肺泡末呼吸氢浓度。立体定向在大鼠中产生六羟基多巴胺（6-OHDA）诱导的半-PD模型。我们比较了氢气和乳果糖对预防PD的作用。我们还分析了连续和间歇给药2％氢气的效果。结果在健康受试者中，氢气在10分钟内使呼吸中的氢浓度从8.6？±？2.1增加到32.6？±？3.3 ppm（平均值和SEM，n？=？8）。乳果糖可提高86％的健康受试者和59％的PD患者的呼吸氢浓度。与71％的健康受试者的单相氢增加相比，PD患者的32％和41％分别表现为双相和无氢。乳果糖还单相增加了9只大鼠的呼吸氢水平。然而，乳果糖可稍微改善大鼠6-OHDA诱导的PD。连续施用2％的氢气同样具有边际效应。另一方面，间歇给药2％氢气可防止6只大鼠中的4只出现PD。结论缺乏氢的剂量响应以及存在氢水和间歇性氢气的有利作用，表明氢的信号调节活性可能在发挥针对PD的保护作用中发挥作用。

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