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The immunomodulatory role of carbon monoxide during transplantation

机译：一氧化碳在移植过程中的免疫调节作用

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The number of organ and tissue transplants has increased worldwide in recent decades. However, graft rejection, infections due to the use of immunosuppressive drugs and a shortage of graft donors remain major concerns. Carbon monoxide (CO) had long been regarded solely as a poisonous gas. Ultimately, physiological studies unveiled the endogenous production of CO, particularly by the heme oxygenase (HO)-1 enzyme, recognizing CO as a beneficial gas when used at therapeutic doses. The protective properties of CO led researchers to develop uses for it, resulting in devices and molecules that can deliver CO in vitro and in vivo. The resulting interest in clinical investigations was immediate. Studies regarding the CO/HO-1 modulation of immune responses and their effects on various immune disorders gave rise to transplantation research, where CO was shown to be essential in the protection against organ rejection in animal models. This review provides a perspective of how CO modulates the immune system to improve transplantation and suggests its use as a therapy in the field.
机译：近几十年来，器官和组织移植的数量在世界范围内有所增加。然而，移植物排斥，由于使用免疫抑制药物引起的感染以及移植物供体的短缺仍然是主要问题。一氧化碳（CO）长期以来一直被视为有毒气体。最终，生理学研究揭示了CO的内源性产生，特别是通过血红素加氧酶（HO）-1酶，它认识到以治疗剂量使用时CO是一种有益的气体。 CO的保护性质促使研究人员开发了它的用途，从而产生了可以在体内外释放CO的装置和分子。对临床研究的兴趣很快产生。有关CO / HO-1免疫应答调节及其对各种免疫疾病的影响的研究引起了移植研究，在动物模型中，CO被证明在防止器官排斥方面至关重要。这篇综述提供了CO如何调节免疫系统以改善移植的观点，并建议将其用作该领域的疗法。

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