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Impact of inhalational anesthetics on postoperative cognitive function: Study protocol of a systematic review and meta-analysis

机译：吸入麻醉药对术后认知功能的影响：系统评价和荟萃分析的研究方案

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Background: Conflict findings of the impact of inhalational anesthetics on postoperative cognitive function are reported. No systematic review has been performed to solve the problem. The aim of the study was to assess the effect of different inhalational anesthetics on postoperative cognitive function in a network meta-analysis . Methods: We will search MEDLINE, EMBASE, the Central Register of Controlled Trials in the Cochrane library, and CINAHL for randomized controlled trials or cohort studies assessing the short-term or long-term cognitive function of elderly patients (over 60 years) receiving major surgeries and inhalational anesthetics (desflurane, isoflurane, sevoflurane, halothane, and nitrous oxide) during surgery. Two reviewers will independently screen study eligibility, extract information from eligible studies, and appraise study quality. The impact of inhalational anesthetics will be assessed through: incidence of postoperative cognitive dysfunction at 1 week, 3 months, 1 year, and over 1 year after surgery; incidence of post-operative delirium; test of postoperative cognitive function . Results: The results of this systematic review and meta-analysis will be published in a peer-reviewed journal. Conclusion: To our knowledge, this systematic review will be the first to evaluate existing research on the incidence of postoperative cognitive function after inhalational anesthetics . Our study will assess the effect of different inhalational anesthetics on postoperative cognitive function . Ethics and dissemination: The review will be finished in December 2017, and the result will be published in a peer-reviewed journal or disseminated through conference posters or abstracts. Review registration number: CRD42017056675 ( www.crd.york.ac.uk/PROSPERO ).
机译：背景：关于吸入麻醉药对术后认知功能影响的冲突发现已有报道。没有进行系统的审查来解决该问题。该研究的目的是通过网络荟萃分析评估不同的吸入麻醉药对术后认知功能的影响。方法：我们将在MEDLINE，EMBASE，Cochrane图书馆中的对照试验中心登记册和CINAHL中进行搜索，以评估接受大剂量治疗的老年患者（60岁以上）的短期或长期认知功能手术期间的手术和吸入麻醉药（地氟醚，异氟烷，七氟醚，氟烷和一氧化二氮）。两名审稿人将独立筛选研究的资格，从符合条件的研究中提取信息并评估研究质量。吸入麻醉药的影响将通过以下方法评估：术后1周，3个月，1年和1年以上的术后认知功能障碍的发生率;术后del妄的发生率;术后认知功能测试。结果：该系统评价和荟萃分析的结果将在经过同行评审的期刊上发表。结论：据我们所知，本系统综述将是第一个评估吸入麻醉后术后认知功能发生率的现有研究的文献。我们的研究将评估不同的吸入麻醉药对术后认知功能的影响。道德与传播：审核将于2017年12月完成，结果将在同行评审期刊上发布，或通过会议海报或摘要进行传播。查看注册号：CRD42017056675（www.crd.york.ac.uk/PROSPERO）。

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