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首页> 外文期刊>Medicine. >Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)?: A prospective study of 100 psychiatric inpatients
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Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)?: A prospective study of 100 psychiatric inpatients

机译：对在精神科住院的神经系统性系统性红斑狼疮（NPSLE）筛查的年轻妇女是否有用？：对100名精神科住院患者的前瞻性研究

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On the basis that diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE) is sometimes difficult and systemic lupus erythematosus (SLE) can present with isolated psychiatric symptoms, we initiated a survey in a psychiatric department to screen for NPSLE in young female inpatients. We prospectively studied consecutive young female patients referred to the department of psychiatry. Antinuclear antibodies (ANA), anti-deoxyribonucleic acid (DNA), and antiextractable soluble nuclear antigens (ENA) in the serum of patients were screened. In case of positive anti-DNA or anti-ENA, the patient was referred to the department of internal medicine. One hundred patients were enrolled, mean age 33.1?±?8.4 years. Most patients presented underlying psychiatric disorders: depression (46%), schizophrenia (13%), anxiety disorder (6%), and personality disorder (10%). A quarter of the cohort did not display underlying psychiatric disorders before hospitalization. Positive ANA ≥1:160 were found in 32 of the 100 patients tested (32%). No patients presented anti-DNA antibodies. One patient had positive anti-sjogr?n's syndrome related antigen A (SSA), but did not present any features of SLE or Sj?gren syndrome. Thus, systematic screening of SLE is not relevant in young women hospitalized in psychiatric department. However, clinicians should keep in mind that SLE can present with pure psychiatric symptoms.
机译：基于神经精神性系统性红斑狼疮（NPSLE）有时难以诊断且系统性红斑狼疮（SLE）可能表现出孤立的精神症状的基础，我们在精神科开展了一项调查，以筛查年轻女性住院患者的NPSLE。我们对转诊至精神科的连续年轻女性患者进行了前瞻性研究。筛选患者血清中的抗核抗体（ANA），抗脱氧核糖核酸（DNA）和抗提取性可溶性核抗原（ENA）。如果抗DNA或抗ENA阳性，则将患者转诊至内科。入组患者100例，平均年龄33.1±8.4岁。大多数患者表现出潜在的精神疾病：抑郁症（46％），精神分裂症（13％），焦虑症（6％）和人格障碍（10％）。队列中有四分之一在住院前未表现出潜在的精神疾病。在接受测试的100例患者中有32例阳性ANA≥1：160（32％）。没有患者出现抗DNA抗体。一名患者的抗干燥综合征综合症抗原A（SSA）阳性，但未表现出SLE或Sjgren综合征的任何特征。因此，对在精神科住院的年轻女性进行系统性SLE筛查是无关紧要的。但是，临床医生应记住，SLE可以表现出纯精神病症状。

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