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Further application of hyperbaric oxygen in prostate cancer

机译：高压氧在前列腺癌中的进一步应用

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Hyperbaric oxygen therapy (HBOT) has been used as an adjuvant treatment for multiple pathological states, which involves hypoxic conditions. Over the past 50 years, HBOT has been recommended and used in a wide variety of medical conditions, clinically in the treatment of ischemic or nonhealing wounds and radiation-injured tissue, and in the treatment of malignancy. The mechanism of this treatment is providing oxygen under pressure which is higher than the atmosphere thus increasing tissue oxygen concentration. When cells get enough oxygen in the microenvironment, they become active and replicate effectively. Prostate cancer is the second most common cancer and the fifth leading cause of cancer death among male around the world. It is estimated that more than 29,000 men died from metastatic prostate cancer in 2014. With the development of the prostate-specific antigen-based screening technology, prostate cancer incidence has increased markedly over time. According to the survey, the morbidity and mortality of prostate cancer have surpassed bladder cancer and renal carcinoma, becoming the most common cancer in urology in Chinese adults. Nowadays, the main solution to deal with prostate cancer is still the surgical ways, including laparoscopic radical prostatectomy and robot-assisted radical prostatectomy. Nevertheless, the complications of the surgical treatment have not been completely avoided. HBOT has gained great clinical recognition over the decade. It has been demonstrated that HBOT has considerable effects on carcinoma, especially on decreasing complications and improving mortality. So, it is important to combine the HBOT with patients who suffer from prostate cancer. This review illuminates the effect and underlying mechanism of the HBOT in prostate cancer for further clinical application.
机译：高压氧疗法（HBOT）已被用作多种病理状态的辅助治疗，这些状态涉及缺氧性疾病。在过去的50年中，推荐使用HBOT并将其用于多种医学状况，临床上用于治疗缺血性或不愈合的伤口和放射损伤的组织，以及用于治疗恶性肿瘤。这种处理的机制是在高于大气压力的压力下提供氧气，从而增加组织中的氧气浓度。当细胞在微环境中获得足够的氧气时，它们将变得活跃并有效复制。在全世界男性中，前列腺癌是第二大最常见的癌症，也是第五大导致癌症死亡的主要原因。据估计，2014年有29,000多名男性死于转移性前列腺癌。随着基于前列腺特异性抗原的筛查技术的发展，前列腺癌的发病率随时间显着增加。根据调查，前列腺癌的发病率和死亡率已超过膀胱癌和肾癌，成为中国成年人泌尿科最常见的癌症。如今，应对前列腺癌的主要解决方案仍然是手术方法，包括腹腔镜前列腺癌根治术和机器人辅助前列腺癌根治术。然而，尚未完全避免手术治疗的并发症。十年来，HBOT在临床上获得了广泛认可。已经证明HBOT对癌症具有相当大的作用，尤其是在减少并发症和提高死亡率方面。因此，将HBOT与患有前列腺癌的患者联合使用非常重要。这篇综述阐明了HBOT在前列腺癌中的作用和潜在机制，以进一步用于临床。

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