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首页> 外文期刊>Medicine. >Malignant Melanoma in African–Americans: A Population-Based Clinical Outcomes Study Involving 1106 African–American Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1988–2011)
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Malignant Melanoma in African–Americans: A Population-Based Clinical Outcomes Study Involving 1106 African–American Patients from the Surveillance, Epidemiology, and End Result (SEER) Database (1988–2011)

机译：非裔美国人的恶性黑色素瘤：一项基于人群的临床结果研究，涉及来自监视，流行病学和最终结果（SEER）数据库的1106名非裔美国人患者（1988-2011年）

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Malignant melanoma accounts for 75% of all skin cancer deaths and is potentially curable if identified early. Although melanoma is rare in African–Americans (AA), it is associated with a worse prognosis than in Caucasians. This study examines the demographic, pathologic, and clinical factors impacting AA melanoma outcomes. Data for 1106 AA and 212,721 Caucasian cutaneous melanoma patients were abstracted from the Surveillance, Epidemiology, and End Result (SEER) database (1988–2011). Data were grouped on the basis of histological subtypes: “Superficial Spreading” (SS), “Nodular” (NM), “Lentigo Maligna” (LM), “Acral Lentiginous” (AL), and “Not otherwise specified” (NOS). Cutaneous malignant melanoma occurs most commonly in the sixth and seventh decade of life. Caucasian patients presented most commonly with trunk melanomas (34.5%), while lower extremity melanomas were more common in AAs (56.1%), P < 0.001. AAs presented with deeper tumors, more advanced stage of disease, and higher rates of ulceration and lymph node positivity than Caucasians. Cancer-specific mortality was significantly higher, while 5-year cancer-specific survival was significantly lower among AAs for NM and AL subtypes. Multivariate analysis identified male gender, regional and distant stage, NM and AL subtypes as independently associated with increased mortality among both ethnic groups. AAs present most often with AL melanoma on the lower extremities, and with deeper and more advanced stage lesions. AAs have higher cancer-specific mortality for NM and LM than Caucasians. Melanoma education for AA patients and health care providers is needed to increase disease awareness, facilitate early detection, and promote access to effective treatment.
机译：恶性黑色素瘤占所有皮肤癌死亡的75％，如果及早发现，可能治愈。尽管黑色素瘤在非裔美国人（AA）中很少见，但与高加索人相比预后更差。这项研究检查了影响AA黑色素瘤预后的人口统计学，病理学和临床因素。从监测，流行病学和最终结果（SEER）数据库（1988-2011年）中提取了1106名AA和212,721名白人皮肤黑色素瘤患者的数据。数据根据组织学亚型进行分组：“表面扩散”（SS），“结节性”（NM），“ Lentigo恶性肿瘤”（LM），“手足性”（AL）和“未另作规定”（NOS） 。皮肤恶性黑色素瘤最常见于生命的第六和第七个十年。白人患者最常出现躯干黑色素瘤（34.5％），而下肢黑色素瘤在AA中更为常见（56.1％），P <0.001。与高加索人相比，AA表现出更深的肿瘤，更晚期的疾病以及更高的溃疡和淋巴结阳性率。在NM和AL亚型的AA中，癌症特异性死亡率显着较高，而5年癌症特异性生存率则显着降低。多变量分析确定男性性别，区域和远期，NM和AL亚型与两个族裔之间死亡率的增加独立相关。 AA最常见于下肢的AL黑色素瘤，以及较深，更晚期的病变。对于白人和男性，AA的癌症特异性死亡率高于白种人。需要对AA患者和医疗保健提供者进行黑素瘤教育，以提高对疾病的认识，促进早期发现并促进获得有效治疗的机会。

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