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首页> 外文期刊>Medicine. >Metabolic changes in normal appearing white matter in multiple sclerosis patients using multivoxel magnetic resonance spectroscopy imaging
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Metabolic changes in normal appearing white matter in multiple sclerosis patients using multivoxel magnetic resonance spectroscopy imaging

机译：多体素磁共振波谱成像分析多发性硬化症患者正常出现的白质的代谢变化

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摘要

Demyelination and axonal degeneration caused by multiple sclerosis (MS) exist in the white matter and not only in the lesion area. Magnetic resonance spectroscopy (MRS) could provide a unique insight into metabolic changes in the normal appearing white matter (NAWM). To evaluate the subtle axonal degeneration and delineate the spatial distribution of metabolite abnormalities in the NAWM in patients with MS. A total of 17 clinically definite relapsing-remitting MS (RRMS) patients and 21 healthy controls were enrolled in this study. 2D 1H magnetic resonance spectroscopic imaging (MRSI) performed at 3 Tesla was used to measure metabolite concentrations in the frontal-parietal-occipital NAWM. Ratios of N-acetyl-aspartate (NAA) and choline (Cho) to creatine (Cr) and Cho to NAA were calculated in each voxel. MS patients showed decreased NAA/Cr and increased Cho/NAA ratios in the NAWM compared to healthy controls. In the parietal NAWM, the extent of NAA/Cr decrease was significantly higher than that in the frontal and parietal-occipital NAWM. Decreased NAA in the NAWM would provide useful metabolic information for evaluation of disease progression in MS. The high extent of NAA decrease in the parietal NAWM helps improve the accuracy of the prediction.
机译：多发性硬化（MS）引起的脱髓鞘和轴突变性不仅存在于病变区域，而且存在于白质中。磁共振波谱（MRS）可以提供对正常出现的白质（NAWM）代谢变化的独特见解。为了评估细微的轴突变性，并描述MS患者NAWM中代谢产物异常的空间分布。这项研究总共招募了17位临床明确的复发缓解型MS（RRMS）患者和21位健康对照。在3特斯拉进行的2D 1H磁共振波谱成像（MRSI）用于测量额顶叶枕NAWM中的代谢物浓度。计算每个体素中N-乙酰天门冬氨酸（NAA）和胆碱（Cho）与肌酸（Cr）的比率以及Cho与NAA的比率。与健康对照组相比，MS患者在NAWM中显示出降低的NAA / Cr和增加的Cho / NAA比。在顶叶NAWM中，NAA / Cr降低的程度明显高于额叶和顶枕NAWM。 NAWM中NAA的减少将为评估MS的疾病进展提供有用的代谢信息。壁NAWM中NAA的高度降低有助于提高预测的准确性。

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