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Fosinopril and amlodipine in the treatment of isolated systolic hypertension

机译：福辛普利和氨氯地平治疗单纯性收缩期高血压

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The aim of this study was to assess the therapeutic effects of fosinopril (F) and amlodipine (A) on regulation and circadian rhythm of blood pressure, and to evaluate left ventricle mass index (LVMI) in patients over 60 years of age with isolated systolic hypertension, after three months of administration period. After one-week placebo run-in period, 60 patients were randomized into two groups, each including 30 patients, to receive either fosinopril or amlodipine for three months. Clinical, echocardiographic examinations and 24h ambulatory blood pressure measurements were performed at baseline, and after 3 months of therapy. The goal blood pressure was ￡ 140/90 mmHg. It was accomplished in more than two thirds of cases (F 76.6%, and A 79.9%), with lower drug doses needed in the group treated with F. In 13 patients goal values were not accomplished, therefore the therapy was prolonged for one additional month, with combination of two drugs. In 10 of these patients (76.9%), adequate regulation of blood pressure was achieved. Both fosinopril and amlodipine efficiently control blood pressure by once-a-day administration, both significantly influencing its circadian rhythm and resulting in regression of myocardial hyperthrophy. Adequate control of blood pressure and beneficial effects on circadian rhythm of blood pressure are achieved with lower doses of fosinopril.
机译：这项研究的目的是评估福辛普利（F）和氨氯地平（A）对血压调节和昼夜节律的治疗作用，并评估60岁以上单纯收缩期患者的左心室质量指数（LVMI）服用三个月后出现高血压。在一周的安慰剂磨合期后，将60例患者随机分为两组，每组包括30例患者，接受福辛普利或氨氯地平治疗三个月。在基线时和治疗3个月后进行临床，超声心动图检查和24小时动态血压测量。目标血压为￡ 140/90 mmHg。在三分之二以上的病例（F 76.6％，A 79.9％）中完成了该治疗，在用F进行治疗的组中需要较低的药物剂量。13例患者未达到目标值，因此又延长了治疗时间一个月，结合两种药物。在这些患者中的10名（76.9％）中，血压得到了适当的调节。福辛普利和氨氯地平均每天给药一次，可有效控制血压，均会显着影响其昼夜节律并导致心肌肥大。用低剂量的福辛普利可实现对血压的充分控制以及对血压昼夜节律的有益影响。

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