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首页> 外文期刊>Medicine. >Variations of plasma D-dimer level at various points of normal pregnancy and its trends in complicated pregnancies: A retrospective observational cohort study
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Variations of plasma D-dimer level at various points of normal pregnancy and its trends in complicated pregnancies: A retrospective observational cohort study

机译：正常妊娠各点血浆D-二聚体水平的变化及其在复杂妊娠中的趋势：一项回顾性观察队列研究

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D-Dimer (DD) is the smallest fragment of plasmin-mediated cleavage of fibrin. There is a progressive increase in DD concentration with advancing gestation in normal pregnancies, making the upper limit of 0.5 μg/ml used in non-pregnant population an unfavorable marker during pregnancy. Coagulation and fibrinolysis parameters are also markedly disturbed in pregnancies complicated by various pathologies. We designed this retrospective observational cohort study to investigate the trimester specific reference range for DD throughout normal pregnancy, and to compare the distribution of DD in third trimester healthy pregnancies and those complicated by preeclampsia (PE), severe preeclampsia (SPE), gestational diabetes mellitus (GDM), premature rupture of membranes (PROM) and preterm premature rupture of membranes (PPROM). In addition, we aimed to determine the diagnostic value of DD in PE and SPE. In this retrospective observational cohort study, 250 normal and 178 complicated pregnancies were included. Normal pregnancies included 88-first trimester, 101-second trimester and 61-third trimester pregnancies. Complicated pregnancy included 34 PE, 44 SPE, 32 GDM, 33 PROM, and 35 PPROM cases during the third trimester. Predefined exclusion criteria were used. The period of gestation (POG) accounted for 41.9% of the variance in DD, with strong correlation between the POG and DD. The trimester specific reference intervals were computed. The distribution for severe preeclampsia was statistically different compared to other categories in the third trimester. This exceptional distribution led to the generation of a receiver operating characteristic (ROC) curve with an area under curve of 0.828, attesting its possible role in predicting severe preeclampsia . We determined trimester specific reference intervals of DD. The role of DD has been explored, and it may be of diagnostic value in severe preeclampsia .
机译：D-二聚体（DD）是纤溶酶介导的纤维蛋白裂解的最小片段。在正常妊娠中，随着妊娠的发展，DD浓度会逐渐增加，使非妊娠人群使用的0.5μg/ ml上限成为怀孕期间的不利标志。凝血和纤溶参数在受各种病理影响的妊娠中也明显受到干扰。我们设计了这项回顾性观察性队列研究，以调查整个正常妊娠中DD的早期妊娠参考范围，并比较DD在妊娠中期健康妊娠和并发先兆子痫（PE），严重先兆子痫（SPE），妊娠糖尿病的妊娠中的分布（GDM），胎膜早破（PROM）和胎膜早破（PPROM）。此外，我们旨在确定DD在PE和SPE中的诊断价值。在这项回顾性观察队列研究中，纳入了250例正常妊娠和178例复杂妊娠。正常妊娠包括88例早孕，101例早孕和61例早孕。妊娠晚期包括妊娠34例，44例SPE，32例GDM，33例PROM和35例PPROM。使用预定义的排除标准。妊娠期（POG）占DD差异的41.9％，POG与DD之间具有很强的相关性。计算了三个月的特定参考间隔。与妊娠晚期的其他类别相比，严重先兆子痫的分布有统计学差异。这种特殊的分布导致生成了接收器工作特性（ROC）曲线，曲线下面积为0.828，证明了其在预测严重先兆子痫中的可能作用。我们确定了DD的三个月特定参考间隔。已经探讨了DD的作用，它在严重先兆子痫中可能具有诊断价值。

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