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首页> 外文期刊>Metabolites >Global Metabolomics of the Placenta Reveals Distinct Metabolic Profiles between Maternal and Fetal Placental Tissues Following Delivery in Non-Labored Women
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Global Metabolomics of the Placenta Reveals Distinct Metabolic Profiles between Maternal and Fetal Placental Tissues Following Delivery in Non-Labored Women

机译：胎盘的全球代谢组学揭示了未劳动妇女分娩后母体和胎儿胎盘组织之间的代谢差异。

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We evaluated the metabolic alterations in maternal and fetal placental tissues from non-labored women undergoing cesarean section using samples collected from 5 min to 24 h following delivery. Using 1 H-NMR, we identified 14 metabolites that significantly differed between maternal and fetal placental tissues (FDR-corrected p -value 0.05), with 12 metabolites elevated in the maternal tissue, reflecting the flux of these metabolites from mother to fetus. In the maternal tissue, 4 metabolites were significantly altered at 15 min, 10 metabolites at 30 min, and 16 metabolites at 1 h postdelivery, while 11 metabolites remained stable over 24 h. In contrast, in the fetal placenta tissue, 1 metabolite was significantly altered at 15 min, 2 metabolites at 30 min, and 4 metabolites at 1 h postdelivery, while 22 metabolites remained stable over 24 h. Our study provides information on the metabolic profiles of maternal and fetal placental tissues delivered by cesarean section and reveals that there are different metabolic alterations in the maternal and fetal tissues of the placenta following delivery.
机译：我们使用分娩后5分钟至24小时收集的样本评估了接受剖宫产的非劳动妇女的孕妇和胎盘组织中的代谢变化。使用1 H-NMR，我们鉴定了14种代谢产物，它们在母胎盘组织和胎儿胎盘组织之间存在显着差异（FDR校正的p值<0.05），母体组织中有12种代谢产物升高，反映了这些代谢物从母亲到胎儿的流量。在产妇组织中，分娩后15分钟有4种代谢物发生了显着变化，分娩后1 h有30种变化，有10种代谢物发生了显着变化，而24小时内有11种代谢物保持稳定。相反，在胎儿胎盘组织中，分娩后15分钟有1种代谢产物发生了显着改变，分娩后1 h有2种代谢产物发生了改变，而在30 min时有4种代谢产物发生了改变，而22种代谢产物在24小时内保持稳定。我们的研究提供了剖宫产产妇和胎盘组织代谢概况的信息，并揭示了产妇在胎盘的产妇和胎儿组织中有不同的代谢变化。

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