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首页> 外文期刊>Metabolites >The Role of Sarcosine, Uracil, and Kynurenic Acid Metabolism in Urine for Diagnosis and Progression Monitoring of Prostate Cancer
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The Role of Sarcosine, Uracil, and Kynurenic Acid Metabolism in Urine for Diagnosis and Progression Monitoring of Prostate Cancer

机译：肌氨酸，尿嘧啶和犬尿酸代谢在尿液中对前列腺癌的诊断和进展监测的作用

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The aim of this pilot study is to evaluate sarcosine, uracil, and kynurenic acid in urine as potential biomarkers in prostate cancer detection and progression monitoring. Sarcosine, uracil, and kynurenic acid were measured in urine samples of 32 prostate cancer patients prior to radical prostatectomy, 101 patients with increased prostate-specific antigen prior to ultrasonographically-guided prostatic biopsy collected before and after prostatic massage, and 15 healthy volunteers (controls). The results were related to histopathologic data, Gleason score, and PSA (Prostate Specific Antigen). Metabolites were measured after analysis of urine samples with Ultra-High Performance Liquid Chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) instrumentation. Multivariate, nonparametric statistical tests including receiver operating characteristics analyses, one-way analysis of variance (Kruskal–Wallis test), parametric statistical analysis, and Pearson correlation, were performed to evaluate diagnostic performance. Decreased median sarcosine and kynurenic acid and increased uracil concentrations were observed for patients with prostate cancer compared to participants without malignancy. Results showed that there was no correlation between the concentration of the studied metabolites and the cancer grade (Gleason score <7 vs. ≥7) and the age of the patients. Evaluation of biomarkers by ROC (Receiving Operating Characteristics) curve analysis showed that differentiation of prostate cancer patients from participants without malignancy was not enhanced by sarcosine or uracil levels in urine. In contrast to total PSA values, kynurenic acid was found a promising biomarker for the detection of prostate cancer particularly in cases where collection of urine samples was performed after prostatic massage. Sarcosine and uracil in urine samples of patients with prostate cancer were not found as significant biomarkers for the diagnosis of prostate cancer. None of the three metabolites can be used reliably for monitoring the progress of the disease.
机译：这项初步研究的目的是评估尿液中的肌氨酸，尿嘧啶和犬尿酸作为前列腺癌检测和进展监测中潜在的生物标志物。在前列腺癌根治术前对32例前列腺癌患者的尿液样本中测定了肌氨酸，尿嘧啶和犬尿酸，对前列腺按摩前后进行超声引导的前列腺穿刺活检前的101例前列腺特异性抗原升高的患者和15名健康志愿者（对照）。结果与组织病理学数据，格里森评分和PSA（前列腺特异性抗原）有关。用超高效液相色谱-串联质谱（UPLC-MS / MS）仪器分析尿液样品后测量代谢物。进行了多变量，非参数统计检验，包括接收器工作特性分析，方差单向分析（Kruskal–Wallis检验），参数统计分析和Pearson相关性，以评估诊断性能。与没有恶性肿瘤的参与者相比，前列腺癌患者的肌氨酸和运动尿酸中值降低，尿嘧啶浓度升高。结果表明，所研究代谢物的浓度与癌症等级（格里森评分<7 vs.≥7）与患者年龄之间没有相关性。通过ROC（接收操作特征）曲线分析对生物标志物的评估表明，尿液中的肌氨酸或尿嘧啶水平并未增强前列腺癌患者与无恶性肿瘤的参与者的区别。与总PSA值相比，发现尿嘧啶酸是一种有前途的生物标志物，可用于检测前列腺癌，尤其是在前列腺按摩后收集尿液样本的情况下。未发现前列腺癌患者尿液中的肌氨酸和尿嘧啶是诊断前列腺癌的重要生物标志物。这三种代谢物均不能可靠地用于监测疾病的进展。

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