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首页> 外文期刊>Mineralogia >Functional Magnetic Resonance Study of Non-conventional Morphological Brains: malnourished rats
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Functional Magnetic Resonance Study of Non-conventional Morphological Brains: malnourished rats

机译：营养不良大鼠的非常规形态大脑的功能磁共振研究

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Malnutrition during brain development can cause serious problems that can be irreversible. Dysfunctional patterns of brain activity can be detected with functional MRI. We used BOLD functional Magnetic Resonance Imaging (fMRI) to investigate region differences of brain activity between control and malnourished rats. The food-competition method was applied to a rat model to induce malnutrition during lactation. A 7T magnet was used to detect changes of the BOLD signal associated with changes in brain activity caused by the trigeminal nerve stimulation in malnourished and control rats. Major neuronal activation was observed in malnourished rats in several brain regions, including cerebellum, somatosensory cortex, hippocampus, and hypothalamus. Statistical analysis of the BOLD signals from various brain areas revealed significant differences in somatosensory cortex between the control and experimental groups, as well as a significant difference between the cerebellum and other structures in the experimental group. This study, particularly in malnourished rats, demonstrates increased BOLD activation in the cerebellum.
机译：大脑发育过程中的营养不良会导致严重的问题，这些问题是不可逆的。可以通过功能性MRI来检测大脑活动的功能异常模式。我们使用BOLD功能磁共振成像（fMRI）来研究对照组和营养不良大鼠之间的大脑活动区域差异。食物竞争法被应用于大鼠模型，以在哺乳期引起营养不良。使用7T磁铁检测营养不良和对照组大鼠的三叉神经刺激引起的与大脑活动变化有关的BOLD信号变化。在营养不良的大鼠的几个大脑区域（包括小脑，体感皮层，海马和下丘脑）中观察到了主要的神经元活化。对来自各个大脑区域的BOLD信号的统计分析显示，对照组和实验组之间的体感皮层存在显着差异，实验组的小脑和其他结构之间也存在显着差异。这项研究，特别是在营养不良的大鼠中，证明了小脑中BOLD激活的增加。

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