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首页> 外文期刊>International Journal of Vascular Medicine >Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative?
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Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative?

机译:冠状动脉支架植入术后氯吡格雷诱发的中性粒细胞减少:西洛他唑是一个很好的选择吗?

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Dual antiplatelet therapy with aspirin plus thienopyridines has become the standard treatment of patients undergoing coronary stenting. Clopidogrel has mostly replaced the use of ticlopidine due to its more favourable adverse event profile. However, also the use of clopidogrel is not without side effects. Clopidogrel major adverse events are represented by marrow suppression, manifesting with aplastic anaemia, thrombocytopenia and neutropenia. When clopidogrel toxicity occurs, there are few and unsubstantiated alternative treatments and thus, in these cases, medical decisions may be very difficult. We report a case of clopidogrel-induced bone marrow toxicity manifesting with severe neutropenia in a patient treated with multiple coronary stents and provide suggestions for an alternative treatment.
机译:阿司匹林加噻吩并吡啶类抗血小板双重疗法已成为接受冠状动脉支架置入术患者的标准治疗方法。氯吡格雷由于其更有利的不良事件特征,已大部分取代了噻氯匹定的使用。但是,使用氯吡格雷也不是没有副作用的。氯吡格雷的主要不良事件以骨髓抑制为代表,表现为再生障碍性贫血,血小板减少和中性粒细胞减少。当发生氯吡格雷毒性时,几乎没有任何未经证实的替代疗法,因此,在这些情况下,医疗决策可能非常困难。我们报告了一例氯吡格雷诱发的骨髓毒性表现为严重中性粒细胞减少症的患者,该患者经多枚冠状动脉支架治疗,并提供了替代治疗建议。

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