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首页> 外文期刊>European Journal of Translational Myology >A mini-review of TAT-MyoD fused proteins: state of the art and problems to solve
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A mini-review of TAT-MyoD fused proteins: state of the art and problems to solve

机译:TAT-MyoD融合蛋白的迷你回顾:最新技术和需要解决的问题

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摘要

The transcriptional activator TAT is a small peptide essential for viral replication and possesses the property of entering the cells from the extracellular milieu, acting as a membrane shuttle. In order to safely differentiate cells an innovative methodology, based on the fusion of transcription factors and the TAT sequence, is discussed in this short review. In several studies, it has been demonstrated that TAT protein can be observed in the cell nucleus after few hours from the inoculation although its way of action is not fully understood. However, further studies will be necessary to develop this methodology for clinical purposes.
机译:转录活化剂TAT是病毒复制必不可少的小肽,具有从细胞外环境进入细胞的特性,起着膜穿梭的作用。为了安全地区分细胞,在这篇简短的综述中讨论了一种基于转录因子和TAT序列融合的创新方法。在几项研究中,已经证明,从接种开始数小时后,就可以在细胞核中观察到TAT蛋白,尽管其作用方式尚不完全清楚。但是,为临床目的开发这种方法将需要进一步的研究。

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