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首页> 外文期刊>European Journal of Translational Myology >Partial cardiac assistance begun immediately after Latissimus Dorsi muscle mobilization and cardiomyoplasty
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Partial cardiac assistance begun immediately after Latissimus Dorsi muscle mobilization and cardiomyoplasty

机译：背阔肌肌肉动员和心肌成形术后立即开始部​​分心脏辅助

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Cardiomyoplasty, in which the latissimus dorsi muscle (LDM) assists the heart, is a relatively new surgical treatment for heart failure. Currently, the LDM is unstimulated for the first two weeks postoperatively, then stimulated for the next four weeks with one or two impulses every other heart beat. We wanted to determine if the LDM could provide assistance earlier than six weeks postoperatively. In four control sheep electrical stimulation (ES) was not applied to the LDM; in four sheep, ES was begun two hours after LDM mobilization; in another four sheep, ES mimicking cardiac assist (work-rest regimen) was added to the protocol twice daily for 30 minutes. In animals with the protocol mimicking cardiac assist, contractile force (CF) changed minimally on days 6, 11, and 16 following two successive 30 minute fatigue tests (98 3%; 102 3%, and 104 2 % respectively). The typical ischemic state of the mobilized LDM was not aggravated with this protocol. The percent area occupied by capillaries increased to 5.04 0.33% (compared with 3.02 0.6% in control muscle). In the control series, CF decreased to 85 4%, 78 3%, and 77 3% on days 6, 11, and 16, respectively. We concluded that a cautious stimulation regimen using a work-rest protocol and a slow rate of contraction does allow for earlier partial cardiac assist.
机译：心肌成形术是一种较新的心力衰竭外科治疗方法，其中背阔肌（LDM）辅助心脏。目前，LDM在术后的前两周不被刺激，然后在接下来的四个星期中每隔一个心跳一次或两次被刺激。我们想确定LDM是否可以在术后六周之前提供帮助。在四个对照羊中，未对LDM施加电刺激（ES）。在四只绵羊中，LDM动员两个小时后才开始ES;在另外四只羊中，将模拟心脏辅助（工作休息方案）的ES每天两次添加到方案中，持续30分钟。在具有模拟心脏辅助方案的动物中，在连续两次30分钟疲劳测试后，收缩力（CF）在第6、11和16天变化最小（分别为98 3％; 102 3％和104 2％）。该方案并未使动员的LDM的典型缺血状态恶化。毛细血管占据的面积百分比增加到5.04 0.33％（相比之下，对照肌肉为3.02 0.6％）。在对照系列中，CF在第6、11和16天分别降至85 4％，78 3％和77 3％。我们得出的结论是，使用工作休息方案和缓慢的收缩速率的谨慎刺激方案确实允许较早的部分心脏辅助。

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