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首页> 外文期刊>European Journal of Translational Myology >Ultrastructural changes in the skeletal muscle of senile rats with significant age-dependent motor deficits
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Ultrastructural changes in the skeletal muscle of senile rats with significant age-dependent motor deficits

机译：具有明显年龄依赖性运动缺陷的老年大鼠骨骼肌超微结构变化

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The anterior tibial (AT) muscle of 6 female Wistar rats aged 35-44 months, was examined by an electron microscopy. Previously, significant age-dependent functional and morphological deficits were found in these rats including [1] a strongly decreased muscle mass and force, [2] muscle stiffness, [3] spontaneous, tonic electromyographic activity, and [4] light-microscopic features of chronic denervation atrophy. In the present study diverse ultrastructural changes were found in muscle which correspond to chronic denervation atrophy. A number of already described abnormalities could be demonstrated in our material. However, sarcoplasmic reticulum (SR) tubular formations and extensive muscle fiber fragmentation have not been previously associated with senile changes in muscle. This can be explained by a very advanced age of our experimental animals and, in consequence, a more advanced denervation atrophy. Therefore it would appear that no single abnormality or set of morphological changes are characteristic of senile skeletal muscle.
机译：通过电子显微镜检查了6只35-44个月大的Wistar雌性大鼠的胫前肌（AT）。以前，在这些大鼠中发现了明显的年龄依赖性功能和形态缺陷，包括[1]肌肉质量和力量大大降低，[2]肌肉僵硬，[3]自发性，强直性肌电图活动和[4]光学显微镜特征慢性神经支配萎缩。在本研究中，在肌肉中发现了多种不同的超微结构变化，这与慢性去神经萎缩相对应。在我们的资料中可以证明许多已经描述的异常。但是，肌浆网（SR）的肾小管形成和广泛的肌纤维断裂以前并未与肌肉的衰老相关。这可以通过我们的实验动物非常老的年龄来解释，因此可以说是更高级的去神经萎缩。因此，似乎没有任何异常或一组形态学改变是老年骨骼肌的特征。

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