Comparative analysis of Emphasis Type="Italic"Adam33/Emphasis mutations in murine lung cancer cell lines by droplet digital PCR, real-time PCR and Emphasis Type="Italic"Insight Onco/Emphasisa?￠ NGS

Soo-Jin Kim; Eunhee Kim; Kyung-Taek Rim

首页> 外文期刊>Molecular & Cellular Toxicology >Comparative analysis of Emphasis Type="Italic"Adam33/Emphasis mutations in murine lung cancer cell lines by droplet digital PCR, real-time PCR and Emphasis Type="Italic"Insight Onco/Emphasisa?￠ NGS

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Comparative analysis of Emphasis Type="Italic"Adam33/Emphasis mutations in murine lung cancer cell lines by droplet digital PCR, real-time PCR and Emphasis Type="Italic"Insight Onco/Emphasisa?￠ NGS

机译：用液滴数字PCR，实时荧光定量PCR和 Insight Onco a？￠比较小鼠肺癌细胞中 Adam33 突变的比较？ NGS

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BackgroundsIn a mouse-based carcinogen bioassay, we can identify lung cancer-specific oncogenic driver mutations in circulating cell-free DNA in the blood prior to autopsy. These mutations could be used as an early biomarker for lung cancer.

机译：背景技术在基于小鼠的致癌物生物测定中，我们可以在进行尸检之前在血液中循环的无细胞DNA中鉴定肺癌特异性致癌驱动基因突变。这些突变可以用作肺癌的早期生物标记。

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《Molecular & Cellular Toxicology》 |2018年第2期|共11页
作者
Soo-Jin Kim; Eunhee Kim; Kyung-Taek Rim;
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中图分类分子生物学;
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A disintegrin and metalloproteinase 33 (Adam33)MouseNon-small-cell lung cancer (NSCLC)PNA-mediated mutant enrichment NGS (Insight Oncou2122 NGS)Whole exome sequencing (WES);

机译：非整联蛋白和金属蛋白酶33（Adam33）小鼠非小细胞肺癌（NSCLC）PNA介导的突变富集NGS（Insight Onco u2122 NGS）整体外显子组测序（WES）;

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Comparative analysis of Emphasis Type="Italic"Adam33/Emphasis mutations in murine lung cancer cell lines by droplet digital PCR, real-time PCR and Emphasis Type="Italic"Insight Onco/Emphasisa?￠ NGS

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