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首页> 外文期刊>Molecular & Cellular Toxicology >Association between angiotensin converting enzyme polymorphism and lead-related hypertensive status in lead-exposed male workers from Korea
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Association between angiotensin converting enzyme polymorphism and lead-related hypertensive status in lead-exposed male workers from Korea

机译：韩国铅暴露男性工人中血管紧张素转化酶基因多态性与铅相关性高血压状态的关系

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This study was investigated the association between Angiotensin Converting Enzyme (ACE) polymorphism on blood lead levels and lead-related blood pressure of exposed male workers from Korea. A cross sectional study involving 786 male lead-exposed workers from Korea was conducted, in which a polymerase chain reaction (PCR)-based strategy was used to differentiate the genotypes of ACE I/D (Insertion/ Deletion) polymorphism. The association of clinical characteristics with genotypes as modifiers was estimated after data adjustment for age, smoking status, drinking status, body mass index and job duration. Genotype and allele frequencies of ACE I/D polymorphism were associated with lead-related diastolic, systolic blood pressure and hypertension status. Blood lead levels were not associated with genotype or allele frequencies of ACE I/D polymorphism. From the present results, it was concluded that I/I (Insertion/Insertion)+ I/D genotypes, and I allele of the ACE gene is a risk factor for lead-related hypertensive status; however, they are not directly associated with blood lead levels.
机译：这项研究调查了血管紧张素转换酶（ACE）多态性与血铅水平和韩国接触的男性工人铅相关的血压之间的关系。进行了一项横断面研究，涉及来自韩国的786名男性铅暴露工人，其中使用了基于聚合酶链反应（PCR）的策略来区分ACE I / D（插入/缺失）多态性的基因型。在对年龄，吸烟状况，饮酒状况，体重指数和工作时间进行数据调整后，估计了临床特征与基因型作为修饰因子的关联。 ACE I / D多态性的基因型和等位基因频率与铅相关的舒张，收缩压和高血压状态有关。血铅水平与ACE I / D多态性的基因型或等位基因频率无关。从目前的结果可以得出结论，ACE基因的I / I（插入/插入）+ I / D基因型和I等位基因是导致铅相关性高血压状态的危险因素。但是，它们与血铅水平没有直接关系。

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