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首页> 外文期刊>Memorias do Instituto Oswaldo Cruz >Lack of Correlation between Seminal and Plasma HIV-1 Viral Loads is Associated with CD4 T Cell Depletion in Therapy-naïve HIV-1 + Patients
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Lack of Correlation between Seminal and Plasma HIV-1 Viral Loads is Associated with CD4 T Cell Depletion in Therapy-naïve HIV-1 + Patients

机译：未经治疗的HIV-1 +患者中精浆和血浆HIV-1病毒载量之间缺乏相关性与CD4 T细胞耗竭有关

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摘要

The present study was conducted to investigate a possible correlation between plasma (PVL) and seminal viral load (SVL) on treatment-naïve HIV-1-infected patients in Vitória, ES, Brazil. We also evaluated whether the progressive immunosuppression associated with HIV disease (as evidenced by declining CD4 T cell counts) has any impact on the correlation between PVL and SVL HIV-1. Viral load on paired blood and semen samples from 56 consecutive treatment-naïve patients were evaluated and compared to CD4 cell counts. Viral load and T cell counts (cells/µl) were determined by NASBA and by flow cytometry, respectively. Overall, a strong positive correlation between PVL and SVL (rho = 0.438, p = 0.001) was observed. However, when patients were grouped according to their CD4 counts, this correlation was only significant among patients with CD4 counts>200 cells/µl. Results presented here demonstrate the existence of a strong correlation between PVL and SVL on patients with CD4 cell counts>200 cells/µl, suggesting that this association may correlate with disease progression.
机译：进行本研究以调查在巴西ES的未接受过HIV-1感染的未成年人中血浆（PVL）与精液病毒载量（SVL）之间的可能相关性。我们还评估了与HIV疾病相关的进行性免疫抑制（如CD4 T细胞计数下降所证明）是否对PVL和SVL HIV-1之间的相关性有任何影响。评估了56名连续未接受过治疗的患者的配对血液和精液样本中的病毒载量，并将其与CD4细胞计数进行了比较。病毒载量和T细胞计数（细胞/微升）分别通过NASBA和流式细胞仪确定。总体而言，观察到PVL和SVL之间有很强的正相关性（rho = 0.438，p = 0.001）。但是，当根据CD4计数对患者进行分组时，这种相关性仅在CD4计数> 200个细胞/微升的患者中才有意义。此处显示的结果表明，CD4细胞计数> 200细胞/ µl的患者PVL和SVL之间存在很强的相关性，表明这种关联性可能与疾病进展相关。

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