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首页> 外文期刊>Modern Chemistry >Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex
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Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex

机译：新型硫磺席夫碱配体及其纳米铜配合物的某些金属配合物的合成，表征，3D建模，生物活性

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Novel solid Co(II), Ni(II), Cu(II) and Zn(II) complexes of sulpha drug Schiff base ligand (HL) derived from condensation of sulphaquinoxaline and naphthaldehyde namely, 2-{4-[(2-hydroxynaphthalen-1-yl) methyleneamino] benzenesulfonamido} quinoxalin (HNMABSQ), in addition new mixed ligand complexes with 8-hydroxyquinoline (8-HQ) or 1,10 Phenanthroline (1,10 Phen) with HL and these metal (II) ions were synthesized. The structure of complexes were proposed in light of analytical, IR, 1H-NMR, Mass, UV-Vis, ESR spectral data, magnetic and thermal studies. The molar conductance data reveal that all the metal chelates were non-electrolytes. The kinetic and thermodynamic parameters for decomposition steps in Co(II), Ni(II) and Cu(II) complexes thermo grams were calculated. On the basis of these studies, most complexes have octahedral geometry but few can attain the square planar arrangement. 3D modeling of the ligand and its metal complexes were studied by PM3 method, also the heat of formations, HOMO, LUMO and dipole moments were calculated to confirm the geometry of the ligand and its complexes. Schiff base ligand and its metal complexes were tested for antimicrobial activities. Nano-Cu- Schiff base complex was synthesized and characterized by scanning electron microscopy (SEM) and its biological activities were studied. The Cu nano complex had higher antibacterial and antifungal activity than the ligand and its metal complexes. Also, all tested compounds inhibited the growth of the liver cancer cell.
机译：磺胺喹喔啉与萘醛缩合即2- {4-[（2-羟基萘）的磺胺药物席夫碱配体（HL）的新型固体Co（II），Ni（II），Cu（II）和Zn（II）配合物-1-基）亚甲基氨基]苯磺酰胺基喹喔啉（HNMABSQ），此外还有与8-羟基喹啉（8-HQ）或1,10邻菲咯啉（1,10 Phen）与HL的新混合配体配合物，这些金属（II）离子是合成的。根据分析，IR，1H-NMR，质量，UV-Vis，ESR光谱数据，磁学和热学研究，提出了络合物的结构。摩尔电导数据显示所有金属螯合物均为非电解质。计算了Co（II），Ni（II）和Cu（II）配合物的热分解克数的动力学和热力学参数。在这些研究的基础上，大多数配合物具有八面体几何形状，但很少能达到正方形平面排列。通过PM3方法研究了配体及其金属配合物的3D建模，还计算了地层热，HOMO，LUMO和偶极矩，从而确定了配体及其配合物的几何形状。测试了席夫碱配体及其金属配合物的抗菌活性。合成了纳米Cu-席夫碱配合物，并用扫描电镜（SEM）表征，研究了其生物学活性。铜纳米配合物具有比配体及其金属配合物更高的抗菌和抗真菌活性。而且，所有测试的化合物均抑制肝癌细胞的生长。

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