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首页> 外文期刊>Molecular biology of the cell >The Fission Yeast Meiotic Regulator Mei2p Forms a Dot Structure in the Horse-Tail Nucleus in Association with the sme2 Locus on Chromosome II
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The Fission Yeast Meiotic Regulator Mei2p Forms a Dot Structure in the Horse-Tail Nucleus in Association with the sme2 Locus on Chromosome II

机译：裂变酵母减数分裂调节剂Mei2p与染色体II上的sme2基因座相关联在马尾核中形成点结构

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Fission yeast Mei2p is an RNA-binding protein essential for induction of both premeiotic DNA synthesis and first meiotic division. Mei2p forms a dot structure at an apparently fixed position in the horse-tail nucleus during meiotic prophase. This dot formation requires a meiosis-specific RNA species, meiRNA, which is indispensable for meiosis I, and the emergence of the dot is an indicator of the ability of the cell to perform meiosis I. Herein, we have sought the identity of this dot. Analyses using chromosome segregation in haploid meiosis, reciprocal translocation of chromosomes, and gene translocation have led us to conclude that the Mei2p dot is in association with the sme2 gene on the short arm of chromosome II, which encodes meiRNA. Transcripts of sme2 , rather than the DNA sequence of the gene, seem to be the determinant of the localization of the Mei2p dot. However, evidence suggests that the dot may not be a simple reflection of the attachment of Mei2p to meiRNA undergoing transcription. We speculate that the Mei2p dot is a specialized structure, either to foster the assembly of Mei2p and meiRNA or to perform some unidentified function indispensable for meiosis I.
机译：裂变酵母Mei2p是诱导前减数分裂DNA合成和第一次减数分裂分裂所必需的RNA结合蛋白。 Mei2p在减数分裂前期在马尾核的明显固定位置形成点结构。这种点的形成需要减数分裂特异的RNA物种meiRNA，这对于减数分裂I是必不可少的，点的出现是细胞进行减数分裂I的能力的指标。在此，我们寻求该点的身份。使用单倍体减数分裂中的染色体分离，染色体的相互易位以及基因易位的分析使我们得出结论，Mei2p点与II号染色体短臂上的sme2基因相关，该基因编码meiRNA。 sme2的转录物，而不是基因的DNA序列，似乎是Mei2p点定位的决定因素。但是，证据表明该点可能不是Mei2p与正在转录的meiRNA的附着的简单反映。我们推测，Mei2p点是一种特殊的结构，可以促进Mei2p和meiRNA的装配，也可以执行减数分裂I必不可少的一些未知功能。

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